Ampicillin: Clinical experience as well as two references indicate non-porphyrinogenicity. The clavulanic acid component does probably not interact with CYPs and is stated in two references to be non-porphyrinogenic.

(To be edited, initial data ST OCT 04) Ampicillin: Broadspectrum penicillin for parenteral use. Metabolized only to a slight extent to penicilloic acid, 72-92 % of the dose excreted unchanged. The antibiotic is combined with the betalactamase inhibitor clavulanic acid, which is extensively metabolized in the liver. No data pointing to CYP-interaction. Ampicillin: South African list: use. Australian list: safe. Clavulanic acid: South African list: use. Australian list: safe.

Uneventful use reported in 51 patients with acute porphyria.