Substrate for CYP 2C9 and 3A4. One list consider it probably safe.

(To be edited, initial data ST OCT 04) Tabl, supp, 7-15 mg/d. Analgetic, antipyretic och anti-inflammatory inhibitor of prostaglandin synthesis used in osteoarthrosis. Oxicam derivative, extensively metabolized by hydroxylation by CYP 2C9 (major reaction) and 3A4 (minor reaction). Inhibitor of CYP 2C9. South African list: use with care

Uneventful use reported in 5 patients with acute porphyria.