Extensively CYP 3A4 metabolised. Conflicting references. Some clinical experience of non-porphyrinogenicity.

(To be edited, initial data ST OCT 04) Benzodiazepine derivative used in attacks of epilepsy. Its effect is based on enhancement of normal GABa transmission. Extensively metabolized via CYP 3A4, the main metabolite being 7-amino-clonazepam. EPI-list: safe South African list: use with care French list: use The Merck Manual: unsafe Australian list: unsafe. Andersson; patient inquiry: used without illeffects (n=2) Peters: According to our experience probably not porphyrinogenic See: Suzuki 1992, Chaix 1997. C.Andersson; patient report: tolerated (n=1). Used in porphyria ward (Sweden).

Uneventful use reported in 16 patients with acute porphyria.