R03AC02 - Salbutamol |
Not porphyrinogenic |
NP |
Rationale
Rather low dose, in large parts excreted unmetabolized. No data pointing to CYP-interaction. Four references consider it safe.
Chemical description
(To be edited, initial data ST OCT 04) Adrenergic beta-receptor stimulating agent used in asthma. Administered as salbutamol sulfate in micronized form in inhalation aerosol (2,5 - 5 mg/dose). No clinical data pointing to CYP-interaction. About 35% of the dose is excreted in unchanged form in urine. EPI-list: safe South African list: use French list: authorized. Kauppinen and Mustajoki. Prognosis of acute porphyria... Medicine 1992; 71: 1-13: tolerated (n=2)C. Andersson, patient reports: tolerated (n=1)
IPNet drug reports
Uneventful use reported in 21 patients with acute porphyria.
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