Monograph
C02CA04 - Doxazosin |
Propably not porphyrinogenic |
PNP |
Rationale
No data pointing to CYP-interaction. Clinical experience of non-porphyrinogenicity.
Chemical description
Quinazoline derivative
Therapeutic characteristics
Antihypertensive quinazoline derivative, also used in prostatic hyperplasia. Dose 4-8 mg/d.
Metabolism and pharmacokinetics
Extensively metabolised in the liver, primarily excreted in faeces as metabolites and only a small amount of unchanged drug. Oxidative metabolism occurs, but data on CYP450 metabolism are lacking.
Personal communication
Thunell, patient reports (n=5): tolerated. Andersson, patient reports(n=11): tolerated.
Published experience
Doxazosin was used uneventfully in 60 year old AIP woman (Gorchein, 1997). Also used uneventfully in AIP man of 55 (Turton-Weeks, 2001).
IPNet drug reports
Uneventful use reported in 19 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Drug treatment of hypertension in acute intermittent porphyria: Doxazosin and amlodipine. British Journal of Clinical Pharmacology 1997; 43(3):339-340.
Gorchein A. |
9088595 |
| 2. | Pretransplant evaluation of a patient with acute intermittent porphyria. Progress in Transplantation 2001; 11(3):214-216.
Turton-Weeks S, Barone GW, et al. |
11949465 |
Tradenames
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Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
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Cardura XL 4, tabletten met gereguleerde afgifte 4 mg · Cardura XL 8, tabletten met gereguleerde afgifte 8 mg · Doxazosine 1 PCH, tabletten 1 mg · Doxazosine 2 PCH, tabletten 2 mg · Doxazosine 4 PCH, tabletten 4 mg · Doxazosine Aurobindo Retard 4 mg, tabletten met verlengde afgifte · Doxazosine Aurobindo Retard 8 mg, tabletten met verlengde afgifte · Doxazosine DOC Generici 2 mg, tabletten · Doxazosine DOC Generici 4 mg, tabletten · Doxazosine retard 4 mg PCH, tabletten met verlengde afgifte · Doxazosine retard CF 4 mg, tabletten met verlengde afgifte · Doxazosine Retard Mylan 4 mg, tabletten met verlengde afgifte · Doxazosine Retard Mylan 8 mg, tabletten met verlengde afgifte · Doxazosine Sandoz retard 4 mg, tabletten met verlengde afgifte · Doxazosine Sandoz retard 8 mg, tabletten met verlengde afgifte 
CARDURAN NEO 4 mg COMPRIMIDOS DE LIBERACION MODIFICADA · Carduran neo 8 mg Comprimidos de Liberacion Modificada · Doxazosina · DOXAZOSINA ALTER 2 mg COMPRIMIDOS EFG · DOXAZOSINA ALTER 4 mg COMPRIMIDOS EFG · DOXAZOSINA AUROBINDO 2 mg COMPRIMIDOS EFG · DOXAZOSINA AUROBINDO 4 mg COMPRIMIDOS EFG · Doxazosina Aurovitas 2 mg Comprimidos efg · Doxazosina Aurovitas 4 mg Comprimidos efg · DOXAZOSINA CINFA 4 mg COMPRIMIDOS EFG · DOXAZOSINA COMBIX 4 mg COMPRIMIDOS EFG · DOXAZOSINA NEO AUROVITAS SPAIN 4 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · DOXAZOSINA NEO AUROVITAS SPAIN 8 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · DOXAZOSINA NEO BEXAL 4 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · Doxazosina neo Cinfa 4 mg Comprimidos de Liberaci?n Prolongada efg · Doxazosina neo Cinfa 8 mg Comprimidos de Liberacion Prolongada efg · DOXAZOSINA NEO RATIOPHARM 4 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · Doxazosina neo Ratiopharm 8 mg Comprimidos de Liberacion Prolongada efg · DOXAZOSINA NEO SANDOZ 8 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · DOXAZOSINA NEO STADA 4 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · DOXAZOSINA NEO STADA 8 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · DOXAZOSINA NEO TEVA 4 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · Doxazosina neo Viatris 4 mg Comprimidos de Liberacion Prolongada efg · Doxazosina neo Viatris 8 mg Comprimidos de Liberacion Prolongada efg · DOXAZOSINA NEO VIR 4 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · DOXAZOSINA NEO ZENTIVA 8 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · DOXAZOSINA NORMON 2 mg COMPRIMIDOS EFG · DOXAZOSINA NORMON 4 mg COMPRIMIDOS EFG · Doxazosina Teva-Ratiopharm 2 mg Comprimidos efg · Doxazosina Teva-Ratiopharm 4 mg Comprimidos efg · Doxazosina Viatris Pharmaceuticals 4 mg Comprimidos efg · DOXAZOSINA VIR 2 mg COMPRIMIDOS EFG · PROGANDOL 2 mg COMPRIMIDOS · PROGANDOL 4 mg COMPRIMIDOS · PROGANDOL NEO 4 mg COMPRIMIDOS DE LIBERACION MODIFICADA · PROGANDOL NEO 8 mg COMPRIMIDOS DE LIBERACION MODIFICADA 
Cardura · Chiaridoxina · Dedralen · Dilur · Doxafin · Doxazosin · Doxazosina · Kimura · Lenaxolan · Noradox · Normothen · Quorum · Saidox 
CARDURA XL 4 mg (vezi G04CAN1) · DOXAZOSIN ARENA 1 mg (vezi G04CAN1) · KAMIREN (vezi G04CAN1) 
Cardozin XL · Cardura · Cardura XL · Cascor · Colixil · Doxadura · Doxazosin · Doxzogen XL · Larbex XL · Oxandosin · Raporsin XL · Slocinx XL 
Cardosin Retard · Carduran Retard · Doxablox · Doxagamma · Doxazosin Carefarm · Doxazosin Epione Medicine · Doxazosin Nordic Prime · Doxazosin Orifarm · Doxazosin Sandoz · Doxazosin Stada · Myocard 
Cardura · Cardura XL · Carduran CR · Carduran Neo · Doxazosin aliud · Doxazosin orifarm · Doxazosine arrow LP · Doxazosine mylan LP 
Adadox · Apo-Doxan 1 · Apo-Doxan 2 · Apo-Doxan 4 · Cardura · Cardura XL · Doxanorm · Doxar · Doxar XL · Doxazosin Aurobindo · Doxazosin Aurovitas · Doxazosin XR Genoptim · Doxonex · Dozox · Kamiren · Kamiren XL · Zoxon 1 · Zoxon 2 · Zoxon 4 
Cardosin Retard · Carduran Retard · Doxazosin Krka 
Cardura · Cardura XL · Doxalfa · Doxazosin Actavis · Doxonex SR · Kamiren · Kamiren XL · Magurol · Zoxon 
Doxazin®
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