Monograph
C03AA03 - Hydrochlorothiazide |
Propably not porphyrinogenic |
PNP |
Rationale
CAVE: Under revision. Clinical experience of non-porphyrinogenicity. Conflicting references, but several references refer to hydrochlorothiazide as safe in acute porphyrias. Hydrochlorothiazide is a sulfonamide congener, but apart from this there are no indications of porphyrinogenicity. Hydrochlorothiazide is not metabolised in the liver and has probably no CYP450 affinity.
Chemical description
Sulfonamide congener.
Therapeutic characteristics
Thiazide diuretic.
Metabolism and pharmacokinetics
Probably no CYP-affinity. Eliminated mainly unchanged in the urine. Seemingly not appreciably metabolized.
Preclinical data
AWAITING (Anderson 1981)
Personal communication
Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Peters: On basis of clinical experience probably not porphyrinogenic.
IPNet drug reports
Uneventful use reported in 9 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Induction of hepatic delta-aminolevulinate synthase and cytochrome P-450 by a thiazide diuretic. [Journal] Hepatology. Vol. 1(5)(pp 1A), 1981.
Anderson KE. Kappas A. |
|
Tradenames
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In some cases, a more comprehensive list of available drug packages is included.
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Hydrochloorthiazide Aurobindo 12,5 mg, tabletten · Hydrochloorthiazide Aurobindo 25 mg, tabletten · Hydrochloorthiazide Aurobindo 50 mg, tabletten · Hydrochloorthiazide Mylan 12,5 mg, tabletten · Hydrochloorthiazide Mylan 25 mg, tabletten · Hydrochloorthiazide Mylan 50 mg, tabletten · Hydrochloorthiazide ratiopharm 25 mg, tabletten · Hydrochloorthiazide Sandoz 12,5 mg glutenvrij, tabletten · Hydrochloorthiazide Sandoz 25 mg glutenvrij, tabletten · Hydrochloorthiazide Sandoz 50 mg, tabletten · Hydrochloorthiazide Teva 12,5 mg, tabletten · Hydrochloorthiazide Teva 25 mg, tabletten · Hydrochloorthiazide Teva 50 mg, tabletten 
Drine 25 mg Comprimidos · Drine 50 mg Comprimidos · ESIDREX 25 mg COMPRIMIDOS · Hidroclorotiazida · Hidroclorotiazida Apotex 25 mg Comprimidos efg · Hidroclorotiazida Apotex 50 mg Comprimidos · Hidroclorotiazida Aristo 25 mg Comprimidos efg · Hidroclorotiazida Aurovitas 25 mg Comprimidos efg · Hidroclorotiazida Aurovitas 50 mg Comprimidos · Hidroclorotiazida Cinfa 12,5 mg Comprimidos · Hidroclorotiazida Cinfa 25 mg Comprimidos efg · Hidroclorotiazida Cinfa 50 mg Comprimidos · Hidroclorotiazida Kern Pharma 25 mg Comprimidos · HIDROCLOROTIAZIDA KERN PHARMA 50 mg COMPRIMIDOS EFG · Hidroclorotiazida Sandoz 25 mg Comprimidos efg · HIDROCLOROTIAZIDA STADA 50 mg COMPRIMIDOS EFG · Hidrosaluretil 25 mg Comprimidos efg · HIDROSALURETIL 50 mg COMPRIMIDOS EFG 
Esidrex · Idroclorotiazide 
NEFRIX 25 mg 
Hydrochlorothiazide · Hydrosaluric 
Hydrochlorothiazide Orifarm · Hydrochlorthiazid 2care4 · Hydrochlorthiazid Nordic Prime · Hydromed 
Esidrex · Hydrochlorothiazide Orifarm · Hydroklortiazid SA · Hydromed 
Hydrochlorothiazide Aurovitas · Hydrochlorothiazide Orion · Hydrochlorothiazidum Polpharma 
Hydromed 
Hydrex · Hydrex Semi 
Hypothiazid 
Diunorm®
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