(CAVE: under revision)Sulfonamide derivative. Conflicting references, but non-metabolism as well as clinical observations point to non-porphyrinogenicity.

Sulfonamide derivative.

Shortacting loop-diuretic.

Primarily excreted by filtration and secretion as unchanged drug. Some liver metabolism may occur. The glucuronide is the most significant metabolite. Non-porphyrinogenic metabolism.

Thunell, patient report (n=2): tolerated. Andersson, patient report (n=9): tolerated.

Two non-English publications seem to involve uneventful exposure of two acute porphyria patients (Lopes Montes 2004, Moeschlin 1975).

Uneventful use reported in 47 patients with acute porphyria.