C07FX03 - Metoprolol and Acetylsalicylic Acid |
Not porphyrinogenic |
NP |
Rationale
Two substances generally believed to be safe. Vast clinical experience of non-porphyrinogenicity.
Chemical description
Beta-blocker (metoprolol) + platelet inhibitor: (acetylsalicylic acid). Metoprolol is metabolized in the liver by CYP2D6. Metoprolol: Thunell, patient reports (n=18): tolerated. Andersson, patient report (n=26): tolerated. South African list: use. French list: authorized. EPI List: safe (betablockers). Acetylsalicylic acid: Kalman/Bonkovsky: believed to be safe. Michael Moore's list: safe. The Merck Manual: safe. Moore/Hift: safe. Eales: safe.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyria and the dangerous life-threatening drugs.
Eales L. S Afr Med J. 1979 Nov; 56(22):914-7.
|
515871 |
| 2. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
Tradenames