Monograph

C08DA01 - Verapamil

Probably porphyrinogenic

Rationale

Substrate of several CYPs, including 3A4. Potent CYP 3A4 inhibitor. Autoactivator of CYP 2B6, probably quantitatively insignificant. Some clinical experience of tolerance. Two references state (probable) non-porphyrinogenicity.

Chemical description

Verapamil / norverapamil: Phenylalkylamine derivatives with calcium antagonistic action. Metabolized by CYPs 2C8, 3A4, 3A5, 2C9, 2E1, 1A2, 2B6, 2C19. Inhibitor of CYPs 2C8, 1A2, 2C9, 3A4 (potent) 2D6, 2C19. Autoactivator of CYP 2B6. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care. Thunell, patient report (n=2): tolerated. Andersson, patient reports: tolerated (n=4). South African list: use with care French list: use. Kauppinen and Mustajoki. Prognosis of acute porphyria: Occurrence of acute attacks, precipitating factors,and assocciated diseases. Medicine 1992; 71, 1-13 : tolerated (n=1).

IPNet drug reports

Uneventful use reported in 4 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C08D / C08DA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Isoptin · Isoptin SR 120, tabletten met gereguleerde afgifte 120 mg · Isoptin SR 180, tabletten met gereguleerde afgifte 180 mg · Isoptin SR 240, tabletten met gereguleerde afgifte 240 mg · Verapamil · Verapamil HCI Eureco-Pharma 2,5 mg/ml, oplossing voor injectie · Verapamil HCl Aurobindo Retard 240 mg, tabletten met gereguleerde afgifte · Verapamil HCl CF 2,5 mg/ml, oplossing voor injectie · Verapamil HCl Dexcel 240 SR, tabletten met gereguleerde afgifte 240 mg · Verapamil HCl Medulent 2,5 mg/ml, oplossing voor injectie · Verapamil HCl retard Teva 120 mg, tabletten met gereguleerde afgifte · Verapamil HCl retard Teva 240 mg, tabletten met gereguleerde afgifte · Verapamil HCl Sandoz 120 mg, filmomhulde tabletten · Verapamil HCl Sandoz 40 mg, filmomhulde tabletten · Verapamil HCl Sandoz 80 mg, filmomhulde tabletten · Verapamil HCl Sandoz retard 120 mg, tabletten met gereguleerde afgifte · Verapamil HCl Sandoz retard 240 mg, tabletten met gereguleerde afgifte

Belgium

Fibrocard · Fibrocard 180 mg gél. lib. prol. · Fibrocard 240 mg gél. lib. prol. · Isoptine · Isoptine 120 mg compr. pellic. · Isoptine 40 mg compr. pellic. · Isoptine 80 mg compr. pellic. · Lodixal · Lodixal 240 mg compr. lib. prol.

United Kingdom

Cordilox · Cordilox 120mg tablets · Cordilox 160mg tablets · Cordilox 40mg tablets · Cordilox 80mg tablets · Cordilox MR · Cordilox MR 240mg tablets · Ethimil MR · Ethimil MR 240mg tablets · Half Securon SR · Half Securon SR 120mg tablets · Ranvera MR · Ranvera MR 240mg tablets · Securon · Securon 120mg tablets · Securon IV · Securon IV 5mg/2ml solution for injection ampoules · Securon SR · Securon SR 240mg tablets · Univer · Univer 120mg modified-release capsules · Univer 180mg modified-release capsules · Univer 240mg modified-release capsules · Vera-Til SR · Vera-Til SR 120mg tablets · Vera-Til SR 240mg tablets · Verapamil · Verapamil 10mg/5ml oral solution · Verapamil 10mg/5ml oral suspension · Verapamil 120mg modified-release tablets · Verapamil 120mg tablets · Verapamil 120mg/5ml oral solution · Verapamil 120mg/5ml oral suspension · Verapamil 160mg tablets · Verapamil 20mg/5ml oral solution · Verapamil 20mg/5ml oral suspension · Verapamil 240mg modified-release tablets · Verapamil 240mg/5ml oral solution · Verapamil 240mg/5ml oral suspension · Verapamil 250mg/5ml oral solution · Verapamil 250mg/5ml oral suspension · Verapamil 30mg/5ml oral solution · Verapamil 30mg/5ml oral suspension · Verapamil 40mg tablets · Verapamil 40mg/5ml oral solution · Verapamil 40mg/5ml oral solution sugar free · Verapamil 40mg/5ml oral suspension · Verapamil 45mg/5ml oral solution · Verapamil 45mg/5ml oral suspension · Verapamil 50mg/5ml oral solution · Verapamil 50mg/5ml oral suspension · Verapamil 80mg tablets · Verapamil 80mg/5ml oral solution · Verapamil 80mg/5ml oral suspension · Verapress MR · Verapress MR 240mg tablets · Vertab SR 240 · Vertab SR 240 tablets · Zolvera · Zolvera 40mg/5ml oral solution

Denmark

Isoptin · Isoptin Retard · Veraloc · Veraloc Retard · Veramacor · Verapamil · Verapamil "2care4" · Verapamil "Epione Medicine" · Verapamil "HEXAL" · Verapamil "Nordic Prime" · Verapamilhydrochlorid · Verapamilhydrochlorid "2care4"

Norway