Monograph
C08DA01 - Verapamil |
Probably porphyrinogenic |
PRP |
Rationale
Substrate of several CYPs, including 3A4. Potent CYP 3A4 inhibitor. Autoactivator of CYP 2B6, probably quantitatively insignificant. Some clinical experience of tolerance. Two references state (probable) non-porphyrinogenicity.
Chemical description
Verapamil / norverapamil: Phenylalkylamine derivatives with calcium antagonistic action. Metabolized by CYPs 2C8, 3A4, 3A5, 2C9, 2E1, 1A2, 2B6, 2C19. Inhibitor of CYPs 2C8, 1A2, 2C9, 3A4 (potent) 2D6, 2C19. Autoactivator of CYP 2B6. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care. Thunell, patient report (n=2): tolerated. Andersson, patient reports: tolerated (n=4). South African list: use with care French list: use. Kauppinen and Mustajoki. Prognosis of acute porphyria: Occurrence of acute attacks, precipitating factors,and assocciated diseases. Medicine 1992; 71, 1-13 : tolerated (n=1).
IPNet drug reports
Uneventful use reported in 4 patients with acute porphyria.
Similar drugs
Tradenames
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Isoptin SR 120, tabletten met gereguleerde afgifte 120 mg · Isoptin SR 180, tabletten met gereguleerde afgifte 180 mg · Isoptin SR 240, tabletten met gereguleerde afgifte 240 mg · Verapamil HCI Eureco-Pharma 2,5 mg/ml, oplossing voor injectie · Verapamil HCl Aurobindo Retard 240 mg, tabletten met gereguleerde afgifte · Verapamil HCl CF 2,5 mg/ml, oplossing voor injectie · Verapamil HCl Dexcel 240 SR, tabletten met gereguleerde afgifte 240 mg · Verapamil HCl Medulent 2,5 mg/ml, oplossing voor injectie · Verapamil HCl retard Teva 120 mg, tabletten met gereguleerde afgifte · Verapamil HCl retard Teva 240 mg, tabletten met gereguleerde afgifte · Verapamil HCl Sandoz 120 mg, filmomhulde tabletten · Verapamil HCl Sandoz 40 mg, filmomhulde tabletten · Verapamil HCl Sandoz 80 mg, filmomhulde tabletten · Verapamil HCl Sandoz retard 120 mg, tabletten met gereguleerde afgifte · Verapamil HCl Sandoz retard 240 mg, tabletten met gereguleerde afgifte 
Fibrocard · Fibrocard 180 mg g?l. lib. prol. · Fibrocard 240 mg g?l. lib. prol. · Isoptine 120 mg compr. pellic. · Isoptine 40 mg compr. pellic. · Isoptine 80 mg compr. pellic. · Lodixal 240 mg compr. lib. prol. 
Manidon · MANIDON 80 mg COMPRIMIDOS CON CUBIERTA PELICULAR · MANIDON HTA 240 mg COMPRIMIDOS DE LIBERACION PROLONGADA · Manidon hta Comprimidos de Liberacion Gradual 
Isoptin · Verapamil 
CORDAMIL 40 mg · CORDAMIL 80 mg · ISOPTIN RR 240 mg · VERAPAMIL ARENA 40 mg · VERAPAMIL ARENA 80 mg 
Cordilox · Cordilox MR · Ethimil MR · Half Securon SR · Ranvera MR · Securon · Securon IV · Securon SR · Univer · Vera-Til SR · Verapamil · Verapress MR · Vertab SR 240 · Zolvera 
Isoptin Retard · Isoptine L.P. · Veraloc · Veraloc Retard · Veramacor · Verapamil 2care4 · Verapamil Epione Medicine · Verapamil HEXAL · Verapamil Nordic Prime · Verapamilhydrochlorid 2care4 
Isoptin · Isoptin Retard · Veramacor · Verapamil 
Isoptin 40 · Isoptin 80 · Isoptin SR · Isoptin SR-E 240 · Staveran 120 · Staveran 40 · Staveran 80 
Isoptin · Isoptin KHK retard · Isoptin Mite · Isoptin RR 
Isoptin retard · Veraloc Retard 
Isoptin Retard · Veramacor · Verpamil 
Isoptin retard 
Isocor® · Verapamil Alkaloid® · Verapamil HF
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