Monograph

C09BA02 - Enalapril and Diuretics

Propably not porphyrinogenic

Rationale

Enalapril: No evidence of CYP-dependent metabolism. Some clinical experience as well as two references point to non- porphyrinogenicity. Hydrochlorothiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence.

Chemical description

Enalapril: ACE-inhibitor. Hydrolyzed to enalaprilate, otherwise not metabolized. Hydrochlorthiazide: Thiazide diuretic. Eliminated in urine in unchanged form. No observations of CYP interaction. Enalapril: Andersson, patient report (n=7) tolerated. South African list: use with care. French list: avoid. Hydrochlorthiazide: South African list: use. French list: authorized. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlorthiazide has been associated with acute attacks of porphyria and is considred unsafe in porphyric patients. EPI-list: sulfonamides are on the unsafe list.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C09B / C09BA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Co-Renitec · Co-Renitec 20/12,5 mg tabletten · Co-Renitec 20/12,5 mg, tabletten · Co-Renitec, tabletten 20/12,5 mg · Enalaprilmaleaat / Hydrochloorthiazide · Enalaprilmaleaat/Hydrochloorthiazide 20/12,5, tabletten 20/12,5 mg · Enalaprilmaleaat/Hydrochloorthiazide CF 20/6 mg, tabletten · Enalaprilmaleaat/Hydrochloorthiazide ratiopharm 20 mg/12,5 mg, tabletten · Enalaprilmaleaat/Hydrochloorthiazide Sandoz 20/12,5 mg, tabletten · Enalaprilmaleaat/Hydrochloorthiazide Sandoz 20/12,5, tabletten 20/12,5 mg · Enalaprilmaleaat/hydrochloorthiazide Sandoz 20/6, tabletten 20 mg/6 mg · Enalaprilmaleaat/Hydrochloorthiazide Viatris 20/12,5 mg, tabletten · Enalaprilmaleaat/HCT · Enalaprilmaleaat/HCT 20/12,5 mg Teva, tabletten

Belgium

Co-Enalapril · Co-Enalapril EG 20 mg - 12.5 mg comp. · Co-Renitec · Co-Renitec 20 mg - 12.5 mg comp.

United Kingdom

Enalapril · Enalapril 20mg / Hydrochlorothiazide 12.5mg tablets · Innozide · Innozide 20mg/12.5mg tablets

Denmark

Corodil Comp · Enacecor · Enalapril / Hydrochlorothiazide · Enalapril/Hydrochlorothiazide "Medical Valley" · Enalapril / Hydrochlorthiazid · Enalapril/Hydrochlorthiazid "Actavis" · Enalapril Hydrochlorthiazid · Enalapril Hydrochlorthiazid "Teva" · Enalapril-Hydrochlorthiazid · Enalapril-Hydrochlorthiazid "Krka" · Lirpalane · Synerpril

Norway

Co-Renitec · Enalapril Comp ratiopharm · Renitec Comp · Renitec Comp Mite

Luxembourg

CO-ENALAPRIL · CO-ENALAPRIL EG · CO-RENITEC

Iceland

Darazíð · Enalapril / Hydrochlorothiazide · Enalapril/Hydrochlorothiazide Medical Valley · Enalapril comp · Enalapril comp Alvogen · Enalapril-Hydrochlorthiazid · Enalapril-Hydrochlorthiazid Krka

Finland

Enalapril Comp Orion · Enalapril comp ratiopharm · Linatil Comp · Renitec Comp

Latvia

EnaHexal Comp · Enap-H · Enap-HL

Serbia

Enalapril/HCT · Enalapril/HCT TEVA · Enap · Enap® - H · Enap® - HL · Enzix · Enzix® · Enzix® duo · Enzix® duo forte

Acute Porphyria Drug Database

Monograph