The two pharmacologically active substances lisinopril and hydrochlorothiazide, are not metabolised.

Lisinopril: ACE-inhibitor. Exceted in urine in unchanged form. Hydrochlorthiazide: Thiazide diuretic, sulfonamide congener Eliminated in urine in unchanged form. Probably no CYP-affinity. Lisinopril: Andersson, patient report (n=7): tolerated. South African list: use with care. French list: authorized. Hydrochlorthiazide: South African list: use. French list: authorized. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlorthiazide has been associated with acute attacks of porphyria and is considred unsafe in porphyric patients. EPI-list: sulfonamides on the unsafe list.

Uneventful use reported in 1 patient with acute porphyria.