Monograph
D07BB03 - Triamcinolone and Antiseptics |
Propably not porphyrinogenic |
PNP |
Rationale
Several references stating non porphyrinogenicity of glucocorticoids. No data on absorption or metabolism of halquinol. Probably insignificant systemic exposure when used in minor quantities.
Chemical description
Creme used in infected dermatoses. Moderately strong glucocorticoid 0.1% combined with the chemotherapeutic halciol (cloxiquine) 0.75% which is a mixture of chlorohydroxyquinoline derivatives with broad action spectrum, including fungal infections. Glucocorticoid: South African list: use Kalman, Bonkovsky: believed to be safe The Merck Manual: use Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939.: safe
Similar drugs
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Alkcema
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