D07XA01 - Hydrocortisone |
Not porphyrinogenic |
NP |
Rationale
Hydrocortisone: Ligand to PXR. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor of CYP 3A4. Several references stating non-porphyrinogenicity. urea: probably not absorbed.
Chemical description
Mild glucocorticoid in combination with the waterbinding agent carbamide. Glucocorticoid: South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: use. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe.
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Other sources | ||
| 3. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
|
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Tradenames
Pimafucort 
Detramax 
Lidocaina e Idrocortisone · Lidoproctene 
Izocon 
Dermacalm-d 
Alphaderm · Calmurid HC · Coal tar / Hydrocortisone · Eurax Hc · Eurax Hydrocortisone · Hydrocortisone / Hydroquinone · Hydrocortisone / Salicylic acid · Hydrocortisone / Sulfur · Hydromol HC Intensive · Nystaform HC · Nystatin 
Fenuril · Hydrocortisone / Salicylic acid · Hydrokortison-svavel 
Hidrocortisona · Hidrortisol · Hidrotex 
Canesten · Cortaid Aloe · Epifoam · Topiderm Hydrocortisone 
Candacort · Hydrocortisone · Ucort 
Pramox 
Pantyson