D07XC02 - Desoximetasone |
Not porphyrinogenic |
NP |
Rationale
The glucocorticoid and ASA components are stated in several references not to be porphyrinogenic. Probably only insignificant systemic exposure.
Chemical description
Strong glucocorticoid, solution 2.5 mg/g, in combination with acetylsalicylic acid for scalp use. Glucocorticoid: South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: use. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe.. Acetylsalicylic acid: South African list: safe. Kalman, Bonkovsky: safe. Michael Moore’s list: safe. The Merck Manual: safe . Eales L: Porphyria and the dangerous lifethreatening drugs, S Afr Med 56:914, 1979: safe.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyria and the dangerous life-threatening drugs.
Eales L. S Afr Med J. 1979 Nov; 56(22):914-7.
|
515871 |
| 2. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Other sources | ||
| 4. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
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Tradenames
Stiedex