Monograph
J01DB03 - Cefalotin |
Propably not porphyrinogenic |
PNP |
Rationale
Cefalotin has no potentially porphyrinogenic pharmacokinetic or pharmacodynamic properties.
Chemical description
Beta-lactam antibiotic.
Therapeutic characteristics
Cefalotin is a semi synthetic first generation parental cephalosporin with a broad spectrum of antibiotic activity. It is used in the treatment of infections and for surgical infection prophylaxis.
Metabolism and pharmacokinetics
Cefalotin is partly metabolized to a less active desacetyl metabolite. 50-75% of the drug is eliminated unchanged in the urine. It has a half-life of 30-50 minutes. Not suspected to have any effect on the activities of cytochrome P450 enzymes.
References
| # | Citation details | PMID |
|---|---|---|
| * | Drug reference publications | |
| 1. | DrugBank. Cefalotin.
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| * | Drug interaction databases | |
| 2. | Lexicomp Online. Martindale: The Complete Drug Reference. Cefalotin Sodium. (27.07.2010)
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| * | Summary of Product Characteristics | |
| 3. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Keflin.
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Similar drugs
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