Monograph

J01XX08 - Linezolid

Propably not porphyrinogenic

Rationale

Linezolid is not metabolised by CYP450 enzymes. Risk for gastrointestinal adverse events in the form of nausea, vomiting and diarrhoea motivates vigilance against insufficient intake of food, especially of carbohydrate.

Chemical description

Linezolid is a member of the antibiotic group oxazolidinones.

Therapeutic characteristics

Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are diarrhoea, vomiting and nausea.

Metabolism and pharmacokinetics

Linezolid is a member of the antibiotic group oxazolidinones. Linezolid is not detectably metabolised by CYP450 enzymes and does not inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4 (SPC). Linezolid demonstrated no response in an hPXR transactivation assay (Sinz 2006).

References

#	Citation details	PMID
*	Scientific articles
1.	Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. Sinz M, Kim S, et al. Curr Drug Metab. 2006 May;7(4):375-88.	16724927
*	Summary of Product Characteristics
2.	Norwegian medicines agency. Summary of Product Characteristics (SPC). Linezolid.

Citation details

PMID

Scientific articles

Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions.

Sinz M, Kim S, et al. Curr Drug Metab. 2006 May;7(4):375-88.

16724927

Summary of Product Characteristics

Norwegian medicines agency. Summary of Product Characteristics (SPC). Linezolid.

Similar drugs

Explore alternative drugs in similar therapeutic classes J01X / J01XX or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Dilizolen · Dilizolen 2 mg/ml, oplossing voor infusie · Grampolid · Grampolid 600 mg, filmomhulde tabletten · Linezolid · Linezolid Accord 600 mg filmomhulde tabletten · Linezolid Eureco-Pharma 2 mg/ml, oplossing voor infusie · Linezolid Farmaprojects 2mg/ml, oplossing voor infusie · Linezolid Fresenius Kabi 2 mg/ml, oplossing voor infusie · Linezolid Mylan 600 mg, filmomhulde tabletten · Linezolid Polpharma 2mg/ml, oplossing voor infusie · Linezolid Polpharma 600 mg, filmomhulde tabletten · Linezolid Sandoz 600 mg, filmomhulde tabletten · Linezolid Teva 600 mg, filmomhulde tabletten · Lynvox · Lynvox 2 mg/ml, oplossing voor infusie · Pneumolid · Pneumolid 2 mg/ml, oplossing voor infusie · Synzolid · Synzolid 600 mg, filmomhulde tabletten · Zyvoxid · Zyvoxid 2 mg/ml, oplossing voor infusie · Zyvoxid 600 mg, filmomhulde tabletten

Belgium

Linezolid · Linezolid Accord 2 mg/ml sol. perf. i.v. · Linezolid Fresenius Kabi 2 mg/ml sol. perf. i.v. · Linezolid Fresenius Kabi 2 mg/ml sol. perf. i.v. flac. · Linezolid Sandoz 600 mg compr. pellic. · Linezolid Viatris 600 mg compr. pellic. · Zyvoxid · Zyvoxid 100 mg/5 ml susp. buv. (gran.) · Zyvoxid 2 mg/ml sol. perf. i.v. · Zyvoxid 600 mg compr. pellic.

United Kingdom

Linezolid · Linezolid 600mg tablets · Linezolid 600mg/300ml infusion bags · Linezolid 600mg/300ml solution for infusion bottles · Zyvox · Zyvox 100mg/5ml granules for oral suspension · Zyvox 600mg tablets · Zyvox 600mg/300ml infusion bags

Denmark

Linezolid · Linezolid "Accord" · Linezolid "Fresenius Kabi" · Linezolid "Glenmark" · Linezolid "Krka" · Linezolid "Sandoz" · Linezolid "Teva" · Zyvoxid

Norway