Monograph

J07BK01 - Varicella, Live Attenuated

Propably not porphyrinogenic

Important Information

In general, vaccines are regarded safe since such substance is not suspected to give an up-regulation of the heme biosynthesis as a direct effect. However, some vaccines can lead to a reaction with high fever persisting over days as a side effect. It is possible that this side effect can trigger an acute porphyric attack in the same way as infections are known to. Vigilance is therefore motivated when administrating a vaccine known to cause reactions with fever.

Side effects

Fever is reported as a very common side effect of the varicella vaccine.

Rationale

Based on the pharmacokinetics of the varicella, live attenuated vaccine, there are no conceivable porphyrinogenic effects.

Chemical description

Live attenuated varicella virus.

Therapeutic characteristics

The varicella vaccine is indicated for active immunization against varicella in individuals from 12 months of age. The vaccine is administered by two intramuscular or subcutaneous injections.

Metabolism and pharmacokinetics

The varicella vaccine is not metabolized by the cytochrome P450 system.

References

#	Citation details	PMID
*	Government bodies
1.	Norwegian Institute of Public Health. Vaksinasjonsveilederen. www.fhi.no (updated 13.10.2015).
*	Summary of Product Characteristics
2.	The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Varivax. (Last edition: November. 2013).

Citation details

PMID

Government bodies

Norwegian Institute of Public Health. Vaksinasjonsveilederen. www.fhi.no (updated 13.10.2015).

Summary of Product Characteristics

The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Varivax. (Last edition:

November. 2013).

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Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Provarivax · Provarivax, poeder en oplosmiddel voor suspensie voor injectie in een voorgevulde spuit

Belgium

Varilrix s.c./i.m. · Varilrix sol. inj. (pdr. + solv.) s.c./i.m. amp. flac. · Varilrix sol. inj. (pdr. + solv.) s.c./i.m. ser. préremplie flac. · Varivax s.c./i.m. · Varivax susp. inj. (pdr. + solv.) s.c./i.m. ser. préremplie flac.

United Kingdom

Varilrix vaccine · Varilrix vaccine powder and solvent for solution for injection 0.5ml vials · Varivax vaccine · Varivax vaccine powder and solvent for suspension for injection 0.5ml vials

Denmark