Monograph
M01AH01 - Celecoxib |
Propably not porphyrinogenic |
PNP |
Rationale
Celecoxib is a substrate of CYP2C9, but does not inhibit CYP2C9 or 3A4. No reports of CYP-inducing effect.
Chemical description
Celecoxib is a diaryl substituted pyrazole derivative containing a sulfonamide substituent.
Therapeutic characteristics
Celecoxib is an NSAID used in the treatment of rheumatoid arthritis including juvenile idiopathic arthritis, osteoarthritis, and ankylosing spondylitis. It is administered orally. Common adverse reactions of celecoxib that can be confused with an acute porphyric attack are abdominal pain, dyspepsia, diarrhoea, and insomnia.
Metabolism and pharmacokinetics
The metabolism of celecoxib is mediated mainly by the cytochrome P450 isoenzyme CYP2C9. Minor substrate of CYP3A4 (Rendic, 2002; Zhou, 2007). Less than 3 % recovered as unchanged rug. Inhibitor of the isoenzyme CYP2D6, but the drug does not inhibit CYP2C9, CYP2C19, or CYP3A4. No observations pointing to CYP-induction in clinical use. Not listed as CYP-inducer.
Personal communication
One report of uneventful use (C.Andersson; patient report).
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Rendic, S. Summery of information on human CYP enzymes: human P450 metabolism. Drug metabolism reviews 2002; 34(1&2), 83-448.
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| 2. | Zhou, S.F., Xue, C.C., et al. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther Drug Monit 2007; 29(6):687:710.
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| * | Drug reference publications | |
| 3. | McEvoy GK, editor. Celecoxib. The AHFS Drug Information 2008. Bethesda, MD: American Society of Health-System Pharmacists; 2009. Electronic version (21.06.10).
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| 4. | Sweetman SC, editor. Martindale: The complete drug reference. Celecoxib. Pharmaceutical Press 2009.
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Bixocel 100 mg, capsules, hard · Bixocel 200 mg, capsules, hard · Celebrex 100 mg, harde capsules · Celebrex 200 mg, harde capsules · Celecoteva 100 mg, harde capsules · Celecoteva 200 mg, harde capsules · Celecoxib Accord 100 mg, harde capsules · Celecoxib Accord 200 mg, harde capsules · Celecoxib Aurobindo 100 mg, harde capsules · Celecoxib Aurobindo 200 mg, harde capsules · Celecoxib CF 100 mg, capsules, hard · Celecoxib CF 200 mg, capsules, hard · Celecoxib Krka 100 mg harde capsules · Celecoxib Krka 200 mg harde capsules · Celecoxib Sandoz 100 mg, capsules, hard · Celecoxib Sandoz 200 mg, capsules, hard · Celecoxib Teva 100 mg, capsules, hard · Celecoxib Teva 200 mg, capsules, hard · Celecoxib Viatris 100 mg harde capsules · Celecoxib Viatris 200 mg harde capsules · Clibex 100 mg, harde capsules · Clibex 200 mg, harde capsules · Licebril 100 mg, capsules, hard · Licebril 200 mg, capsules, hard 
Celebrex · Celebrex 100 mg g?l. · Celebrex 200 mg g?l. · Celecoxib · Celecoxib AB 100 mg g?l. · Celecoxib AB 200 mg g?l. · Celecoxib EG 100 mg g?l. · Celecoxib EG 200 mg g?l. · Celecoxib KRKA 100 mg g?l. · Celecoxib KRKA 200 mg g?l. · Celecoxib Sandoz 100 mg g?l. · Celecoxib Sandoz 200 mg g?l. · Celecoxib Teva 100 mg g?l. · Celecoxib Teva 200 mg g?l. · Celecoxib Teva Generics 100 mg g?l. · Celecoxib Teva Generics 200 mg g?l. 
ARTILOG 100 mg CAPSULAS DURAS · Artilog 200 mg Capsulas Duras · Axatal · Axatal 200 mg c?Psulas Duras efg · Celebrex · Celebrex 200 mg Capsulas Duras · Celecoxib · Celecoxib Almus 200 mg Capsulas Duras efg · Celecoxib Alter 200 mg Capsulas Duras efg · Celecoxib Apotex 200 mg Capsulas Duras efg · Celecoxib Aurovitas 200 mg Capsulas Duras efg · Celecoxib Brill Pharma 100 mg Capsulas Duras efg · Celecoxib Brill Pharma 200 mg Capsulas Duras efg · Celecoxib Cinfa 200 mg Capsulas Duras efg · Celecoxib Ferrer 200 mg Capsula Dura efg · Celecoxib Kern Pharma 100 mg Capsulas Duras efg · Celecoxib Kern Pharma 200 mg Capsulas Duras efg · Celecoxib Krka 100 mg Capsulas Duras efg · Celecoxib Mabo 200 mg Capsulas Duras efg · Celecoxib Mylan Pharmaceuticals 200 mg Capsulas Duras efg · Celecoxib Normon 200 mg Capsulas Duras efg · Celecoxib Opko 100 mg Capsulas Duras efg · Celecoxib Opko 200 mg Capsulas Duras efg · Celecoxib Pensa 200 mg c?Psulas Duras efg · Celecoxib Pensa 200 mg Capsulas Duras efg · Celecoxib Pharmakern 200 mg Capsulas Duras efg · Celecoxib Ratiopharm 200 mg Capsulas Duras efg · Celecoxib Sandoz 200 mg Capsulas Duras efg · Celecoxib Stada 200 mg Capsulas Duras efg · Celecoxib sun 200 mg Capsulas Duras efg · Celecoxib Tarbis Farma 200 mg Capsulas Duras efg · Celecoxib Tecnigen 200 mg Capsulas Duras efg · Celecoxib Teva 200 mg Capsulas Duras efg · Celecoxib Teva-Ratio 200 mg Capsulas Duras efg · Celecoxib uxa 200 mg Capsulas Duras efg · Celecoxib Viatris 200 mg Capsulas Duras efg · Celecoxib vir 200 mg Capsulas Duras efg · Celecoxib Zentiva 200 mg Capsulas Duras efg · Celenib 200 mg Capsulas Duras efg · Meticel 200 mg Capsulas Duras efg · Oxibin 
Celartrox · Celebrex · Celecoxib · Coxart · Coxiben 
ACLEXA 100 mg · ACLEXA 200 mg · ALGOXIB 100 mg · ALGOXIB 200 mg · CELEBREX 100 mg · CELEBREX 200 mg · CELECOXIB TERAPIA 100 mg · CELECOXIB TERAPIA 200 mg · CELECOXIB TEVA 100 mg · CELECOXIB TEVA 200 mg · CELECOXIB TEVA BV 100 mg · CELECOXIB TEVA BV 200 mg 
Celebrex · Celecoxib · Onsenal 
Celebra · Celecoxib Accord · Celecoxib Krka · Celecoxib Medical Valley · Celecoxib Stada 
Celebra · Celebrex · Celecoxib Medical Valley 
Aclexa · Celbic · Celebrex · Celecoxib Accord · Elecoxel · Zelsiglat 
Celebrex · Celecoxib EG · Celecoxib-ratiopharm 100mg · Celecoxib-ratiopharm 200mg 
Celebra · Celecoxib Actavis · Celecoxib Medical · Celecoxib STADA · Celecoxib Teva · Cloxabix 
Celebra · Celecoxib Krka · Celecoxib Stada · Celecoxib Viatris 
Celebrex · Celecoxib Accord · Celecoxib Inteli · Celecoxib Zentiva
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