M02AA13 - Ibuprofen

Not porphyrinogenic

Rationale

Probably insignificant systemic exposure.

Chemical description

Gel 5%. Analgetic and antiinflammatory gel for dermal application effective through its cyclooxygenas inhibiting effect. Hydroxylated by CYP2C9 (major enzyme) and 2C8. Inhibitor of CYP 2C9. Excreted as two metabolites. No data pointing to CYP-induction No data on systemic exposure but is considerd low. South African list: use. French list: avoid.

IPNet drug reports

Uneventful use reported in 4 patients with acute porphyria.

Similar drugs

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References

Tradenames

Show more details and information about the listed tradenames

Nurofen

Extrapan Ibuprofenum · Ibuprofen gel · Nurofen

Aragel · Articalm · Azodermol · Diltix · Gelib · Ibucalm · Ibudol · Ibufen · Ibukey · Ibuprofen gel · Ibustick · Novidol · Nurofen gel · Rolibfar

Deep Relief · Dolgit · Ibuprofen · Nurofen

Biofen · Dolgit · Ibuprofen · Ibutop · Larofen · Nurofen · Nurofen gel · Salipren

Dolocyl

Boots Ibuprofen · Boots Ibuprofen Max Strength · Cuprofen · Fenbid · Fenbid Forte · Ibucalm Ibuprofen Pain Relief · Ibuderm · Ibugel · Ibugel Forte · Ibuleve · Ibuleve Max Strength Pain Relief · Ibuleve Maximum Strength · Ibuleve Pain Relief · Ibuleve Speed Relief · Ibuleve Speed Relief Max Strength · Ibuleve Sports · Ibumousse · Ibuprofen · Ibuprofen gel · Ibuspray · Ibutop Ralgex Ibuprofen · Lloydspharmacy Maximum Strength Ibuprofen · Mentholatum Ibuprofen · Numark Ibuprofen Pain Relief · Nurofen gel · Nurofen plaster · Phorpain · Phorpain Maximum Strength · Proflex · Proflex Pain Relief · Radian B Ibuprofen