M03AC04 - Atracurium |
Probably not porphyrinogenic |
PNP |
Rationale
Non-CYP dependent metabolism. Two references consider it (probably) safe. Reports of safe use. Porphyrinogenic in rat model.
Chemical description
Dibenzene sulfonate salt of a bisquarternary polycyclic ammonium compound. Used for muscle relaxation in anaesthesia. Metabolized non-enzymatically by Hofmann elimination and by ester hydrolysis via unspecific plasma esterases. South African list: use with care. French list: authorized Tanaka and Okimura PMID 7616668: safe
Schmidt et al PMID 1751652: safe. Lin and Chen PMID 2400124: safe.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | [Surgical and anesthetic managements of patients with porphyria].
Ii C, Tanaka N, Okamura H. Nihon Rinsho. 1995 Jun; 53(6):1498-502.
|
7616668 |
| 2. | Atracurium in a patient with acute intermittent porphyria.
Lin YC, Chen L. Anesth Analg. 1990 Oct; 71(4):440-1.
|
2400124 |
| 3. | [Muscle relaxation using atracurium in porphyria variegata--case notes].
Schmidt H, Augenstein T, Böhrer H. Anasthesiol Intensivmed Notfallmed Schmerzther. 1991 Oct; 26(6):311-4.
|
1751652 |
Tradenames
Atracurium · Tracrium 
Atracurium · Tracrium 
Besilato Atracurio · Tracrium 
Atracurium · Tracrium 
Acurmil 
Atracurium 
Atracurium · Tracrium 
Atracurium besilate · Tracrium 
Atracurium · Atrasyl · Tracrium 
Atracurium · Tracrium 
Atracurium · Tracrium 
Atracurium · Tracrium 
Atracurium · Notrixum · Tracrium 
Nimbex · Tracrium 
Atracurium · Atrakurio besilatas · Besilato atracurio · Tracrium 
Atracurium · Tracrium 
Atracurium · Atrakuuriumbesilaat · Tracrium 
Atracurium · Atrakurijev Besilat · Tracrium 
Atracurium · Tracrium