N02AG04 - Hydromorphone and Antispasmodics |
Probably not porphyrinogenic |
PNP |
Rationale
Hydromorphone: Opioid. References consider it safe/probably safe. Atropine: No data pointing to CYP-interaction Several references consider it safe.
Chemical description
Hydromorphone: opioid analgesic metabolized to a large extent and excreted in urine in conjugated form. Atropine:Tertiary amine spasmolytic. No data pointing to CYP-interation. Hydromorphone: Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: probably safe Atropine: MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe Australian list: safe. South African list: use . French list: use. Kalman, Bonkovsky: belived to be safe. Moore MR, Hift RJ, Drugs in the acute porphyrias - toxicogenetic diseases. Cell Mol Biol 43:89, 1997: safe Eales L: Porphyria and the dangerous life-threatening drugs. S Afr. med J 56:914, 1979: safe
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyria and the dangerous life-threatening drugs.
Eales L. S Afr Med J. 1979 Nov; 56(22):914-7.
|
515871 |
| 2. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
Tradenames
Extempore N02AG04 Hydromorfon spasmolytika · Hydromorfon-Atropin · Hydromorfon-Atropin-Haloper · Palladon Comp