Substrate for 3A4. Ligand to PXR and light to moderately strong inducer of CYP 3A4.

Tabl; 200-1000 mg/d. Sulfamate substituted monosaccharide used for additional treatment in patients with partial or generalized epileptic attacks. Metabolized by CYP 3A. Nallani et al. Topiramate. An antiepileptic agent that activates pregane X receptror and induces cytochrome P450 3A4 enzyme. Drug metab Rev Abstr 8th Europ Meeeting, Dijon….2003: Vol 35; Abs 159, p 80.

Uneventful use reported in 1 patient with acute porphyria.