Monograph
N03AX14 - Levetiracetam |
Propably not porphyrinogenic |
PNP |
Rationale
Non-oxidative metabolism. No data pointing to CYP-interaction.
Chemical description
Pyrrolidone derivative used in additional treatment of partial epileptic attacks.The major metabolic pathway (24 % of the dose) is an enzymatic hydrolysis of the acetamide group. Does not interact with CYPs. See: Paul and Meencke. Levitiracetam in focal epilepsia and hepatic porphyria: a case report. Epilepsia 2004; 45: 559-60 ( No exacerbation noed)
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
Similar drugs
References
Tradenames
Dretacen · Keppra · Levetiracetam · Matever · Trund 
Keppra · Levetiracetam · Matever 
Evexibam · Keppra · Laurak · Levetiracetam · Tirbas · Trund 
Epiletam · Keppra · Levetiracetam · Levil · Matever 
Epitiram · Grifoxina · Italept · Keppra · Levetiracetam · Matever · Unipitiram 
Levetiracetam 
Keppra · Laurak · Levetiracetam 
Desitrend · Eltam · Genlev · Keppra · Kevesy · Levetiracetam · Levetiracetam 1000mg/110ml in Sodium chloride 0.9% infusion bags · Levetiracetam 1500mg/115ml in Sodium chloride 0.9% infusion bags · Levetiracetam 500mg/105ml in Sodium chloride 0.9% infusion bags · Matever 
Keppra · Kevesy · Levetiracetam · Matever · Tilamir 
Keppra · Levetiracetam · Spritam 
Cezarius · Keppra · Lepsitam · Levebon · Levetiracetam · Matever · Normeg · Polkepral · Pterocyn · Trund · Vetira 
Keppra · Levetiracetam 
Keppra · Levetiracetam · Matever · Tilamir 
Keppra · Levetiracetam · Matever · Tilamir 
Dretacen · Keppra · Levetiracetam · Levetiracetamas · Matever · Prepalepan 
Keppra · Levetiracetam · Matever 
Keppra · Levetiracetam · Matever · Normeg · Prepalepan 
Aflothenol · Epilev · Keppra · Levetiracetam · Lyvam · Quetra · Zanida 
Keppra · Levetiracetam · Lyvam · Matever · Normeg