N05AA01 - Chlorpromazine |
Not porphyrinogenic |
NP |
Rationale
Neuroleptic, frequently used in acute porphyria without any adverse effects. No indications of CYP-inducing effects. Several references state non-porphyrinogenicity. Since long recommended for use during acute porphyric crises.
Chemical description
High-dose neuroleptic phenothiazine with aliphatic side chain. Broad therapeutic spectrum including antipsychotic, sedative and antiemetic effects. Metabolized by CYP 2D6. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use (phenothiazines). EPI-list: safe Australian list: safe Merck: safe South African list: use French list: use Kalman, Bonkovsky: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
IPNet drug reports
Uneventful use reported in 14 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
Tradenames
Largactil 
Largactil 
Largactil 
Chlorazin · Chlorpromazine · Largactil · Largactil Forte 
Chlorpromazine · Hibernal · Largactil · Largactil Pharmel · Largactil Teofarma 
Chlorpromazine · Largactil 
Fenactil 
Chlorpromazine · Largactil · Largactil Forte 
Chlorpromazine · Largo 
Chlorpromazine 
Fenactil · Largactil 
Hlorpromazin 
Chlorazin · Fenactil · Largactil 
Elmarin · Largactil · Megaphen · Thorazine 
Clorpromazina 
Chlorpromazine