N05AA02 - Levomepromazine

Not porphyrinogenic

Rationale

Chemically and metabolically similar to chlorpromazine (safe). No indications of CYP-inducing effects. Several references consider it safe to use.

Chemical description

High-dose phenothiazine neuroleptic used in psychoses and in treatment of severe pain (central analgesic effect). Strong histamine antagonist. Metabolized by CYP 2D6. No data pointing to CYP-induction. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use. (phenothiazines). EPI-list: safe. French list: use. Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe. Andersson; patient inquiry: used without illeffects (n=1). Thunell; patient inquiry: tolerated (n=1). See: Kassman T et al. Lens opacities and phorphobili... (PMID:6077783). Weiss O et al Methotrimeprazine in acute porphyria (PMID 7089770).

IPNet drug reports

Uneventful use reported in 6 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes N05A / N05AA or go back.

References

#	Citation details	PubMed ID
1.	Lens opacities and porphobilinogen-like substance in urine associated with levomepromazine. Kassman T, Wetterberg L. Acta Psychiatr Scand. 1967; 43(2):163-8.	6077783
2.	Drugs in the acute porphyrias--toxicogenetic diseases. Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.	9074793
3.	Methotrimeprazine in acute porphyria. Weis O, Sriwatanakul K, Weintraub M. S Afr Med J. 1982 Jun; 61(26):985-6.	7089770