Monograph
N05BA04 - Oxazepam |
Propably not porphyrinogenic |
PNP |
Rationale
Directly conjugated with glucuronic acid. References consider it safe
Chemical description
Benzodiazepine with anxiolytic, sedative and muscle relaxing properties. Rapidly and directly glucuronidated due to an active OH-group( not present in diazepam, clopoxide or nitrazepam). Does not form any active metabolites and is eliminated by the kidneys with a half time of 10 hours. Conflicting experimental evidence of porphyrinogenicity (Martindale). MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care (benzodiazepines) Australian list: unsafe (conflicting evidence) South African list: use with care French list: use. Thunell, patient inquiry: tolerated (n=1).
IPNet drug reports
Uneventful use reported in 20 patients with acute porphyria.
Similar drugs
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