N05CM06 - Propiomazine |
Not porphyrinogenic |
NP |
Rationale
phenothiazine, extensively metabolised in the liver. Several references consider it safe for use. Clinical experience and results of patient inquiry point to non-porphyrinogenicity.
Chemical description
Hypnotic phenothiazine derivative, extensively metabolized in the liver. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use (phenothiazines). Kalman, Bonkovsky: safe. Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis,..... Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe. S.Thunell; patient inquiry: used without illeffects (n=5) Andersson:
IPNet drug reports
Uneventful use reported in 8 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
Tradenames
Propavan · Propiomazin 
Propavan 
Propiomazina 
Propiomazine