A07EA01 - Prednisolone |
Probably not porphyrinogenic |
PNP |
Rationale
Partly absorbed. Substrate for CYP 3A4, 3A7 and 11B2. Selective inducer of CYP 3A4. Vast experience and several references indicate non-porphyrinogenicity of glucocorticoids.
Chemical description
Glucocorticoid used as clysma in proctitis and ulcerating colitis. About 40% absorbed. Metabolized mainly by CYP 11B2 and 3A4. Selective inducer of CYP 3A4. South African list: use. French list: authorized. Merck Index: safe Kahlman, Bonkowky: Believed to be safe. Tschudy DP, Lamon JM. Porphyria metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan’s diseases of metabolism. Philadelphia: safe.
IPNet drug reports
Uneventful use reported in 4 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Other sources | ||
| 1. | French List
Centre Français des Porphyries
|
|
| 2. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
|
|
Tradenames
Predenema · Predfoam · Prednisolone · Prednisolone sodium phosphate · Predsol 
Prednisolon 
Pred-Clysma · Prednisolon 
Prednisolon 
Metilprednisolona 
Predsol