Neostigmine: Probably not interfering with hepatic CYPs. References consider it safe. Glycopyrrone: Not metabolised. References consider it safe

A combination of an anticholinergic and a cholinesterase inhibitor used for reversal of non-depolarisation neuromuscular blockade Neostigmine: Cholinesterase inhibitor of short duration. No data pointing to CYP-interaction. Glucopyrrone: Quarternary ammonium compound with anticholinergic properties. Ionized at physiological pH. Rapidly excreted in unchanged form in urine. Neostigmine: MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe South African list: use Glycopyrrone: MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe