Acute Porphyria Drug Database

Monograph

N07BA01 - Nicotine
Propably not porphyrinogenic
PNP

Rationale
Probably no clinically significant CYP-interactions.
Chemical description
The preparation is used in antismoking cure as slow release adhesive (5-16mg/16h), chewing-gum (2-4 mg), nasal spray (0,5 mg/dose), inhalator (10 mg), sublingual resoriblette (2 mg) or lozenge (1 mg). Metabolized in liver, lung and kidneys. More than 20 metabolites are identified,the main metabolite being kotinine. Possibly a CYP1A2-inhibitor. Inducer of CYPs 1A1 and 2E1. (Smoking, but not nicotine, is associated with induction of CYP 1A2).
IPNet drug reports
Uneventful use reported in 2 patients with acute porphyria.
Similar drugs
Explore alternative drugs in similar therapeutic classes N07B / N07BA or go back.
Tradenames
This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.


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