R01AD05 - Budesonide |
Not porphyrinogenic |
NP |
Rationale
Probably insignificant systemic exposure. Several references stating non-porphyrinogenicity of glucocorticoids.
Chemical description
Glucocorticoide with strong antiinflammatory effect used in nasal spray in allergic and vasomotor rhinitis. The amount of budesonide in each dose is 50 - 100 µg. Systemic exposure 33%. Used in porphyria ward (Sweden). EPI-list: safe French list: authorized. South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Other sources | ||
| 3. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
|
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Tradenames
Budesonide 
Budesonide · Rhinocort 
Budena · Budesonida · Rhinocort 
Aircort · Eltair · Kesol 
Budesonid · Cortinasal 
Aircort · Benacort · Budeflam Aquanase · Budesonide · Rhinocort Aqua · Rhinocort Aqua 64 
Benarhin · Budesonid 
Budesonid · Desonix · Livicort · Rhinocort 
Budesonid · Livicort 
Tafen 
b-Cort · Corbuton 
Amcal Budesonide · Butacort · Eltair · Eltair Forte · Hayclear · Rhinocort · SteroClear 
Budesonide · Esonide 
Budesonide · Rhinocort 
Rhinocort 
Rhinocort 
Budesonid 
Budesonid 
Tafen 
Tafen 
Tafen · Tinkair