Monograph
R03BA02 - Budesonide |
Not porphyrinogenic |
NP |
Rationale
Inducer of 3A5. Probably quantitatively insignificant metabolic exposure Several references stating non-porphyrinogenicity of glucocorticoids. Significant clinical experience of non-porphyrinogenicity.
Chemical description
Corticosteroide in inhalation aerosol (50 ug/dose)l, used in treatment of asthma. Systemic bioavailability about 26 %. Metabolized by CYP 3A4. C.Andersson, patient reports: tolerated (n=8). Used in porphyria ward (Sweden). glucocorticoids EPI-list: safe South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncans Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
IPNet drug reports
Uneventful use reported in 21 patients with acute porphyria.
Similar drugs
Tradenames
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Budesonide · Budesonide 1000 microgram/2ml, Focus Care, vernevelsuspensie · Budesonide 200 Cyclocaps, inhalatiepoeder in harde capsule 200 microgram · Budesonide 400 Cyclocaps, inhalatiepoeder in harde capsule 400 microgram · Budesonide 500 microgram/2ml, Focus Care, vernevelsuspensie · Budesonide Allgen 200 CFK-vrije a?rosol, a?rosoloplossing 200 microgram/dosis · Budesonide Novolizer 200 microgram, inhalatiepoeder · Budesonide Novolizer 400 microgram, inhalatiepoeder · Budesonide Orion 100 Easyhaler, inhalatiepoeder, 100 microgram/dosis · Budesonide Orion 200 Easyhaler, inhalatiepoeder, 200 microgram/dosis · Budesonide Orion 400 Easyhaler, inhalatiepoeder, 400 microgram/dosis · Budesonide Sandoz 0,25 mg/ml, vernevelsuspensie in ampul · Budesonide Sandoz 0,5 mg/ml, vernevelsuspensie in ampul · Budesonide Teva Steri-Neb 0,25 mg/2 ml, vernevelsuspensie · Budesonide Teva Steri-Neb 0,5 mg/2 ml, vernevelsuspensie · Budesonide Teva Steri-Neb 1 mg/2 ml, vernevelsuspensie · Pulmicort 
Budesonid · Budesonid Sandoz 0.25 mg/ml susp. inhal. n?bul. amp. · Budesonid Sandoz 0.5 mg/ml susp. inhal. n?bul. amp. · Budesonide · Budesonide Easyhaler 100 ?g pdr. inhal. r?cip. multidos. · Budesonide Easyhaler 200 ?g pdr. inhal. r?cip. multidos. · Budesonide Easyhaler 400 ?g pdr. inhal. r?cip. multidos. · Budesonide EG 0.25 mg/ml susp. inhal. n?bul. amp. · Budesonide EG 0.5 mg/ml susp. inhal. n?bul. amp. · Budesonide Teva 0.125 mg/ml susp. inhal. n?bul. amp. · Budesonide Teva 0.25 mg/ml susp. inhal. n?bul. amp. · Budesonide Teva 0.5 mg/ml susp. inhal. n?bul. amp. · Miflonide · Miflonide Breezhaler 200 ?g pdr. inhal. (g?l.) r?cip. multidos. · Novolizer Budesonide 200 ?g pdr. inhal. cart. · Novolizer Budesonide 400 ?g pdr. inhal. cart. · Pulmicort 
Budena 0,25 mg/ml Suspension Para Inhalacion por Nebulizador · Budena 0,5 mg/ml Suspension Para Inhalacion por Nebulizador · Budesonida · BUDESONIDA ALDO UNION 200 microgramos/pulsaci?n SUSPENSI?N PARA INHALACI?N EN ENVASE A PRESI?N · BUDESONIDA ALDO-UNION 0,25 mg/ml SUSPENSION PARA INHALACION POR NEBULIZADOR · BUDESONIDA ALDO-UNION 0,5 mg/ml SUSPENSION PARA INHALACION POR NEBULIZADOR · Budesonida Aldo-Union 100 Microgramos/Pulsacion Suspension Para Inhalacion en Envase a Presion · BUDESONIDA ALDO-UNION 50 microgramos/pulsaci?n SUSPENSI?N PARA INHALACI?N EN ENVASE A PRESI?N · BUDESONIDA EASYHALER 100 microgramos POLVO PARA INHALACION · BUDESONIDA EASYHALER 200 mcg POLVO PARA INHALACION · BUDESONIDA EASYHALER 400 microgramos POLVO PARA INHALACION · BUDESONIDA PULMICTAN 200 microgramos/INHALACION SUSPENSION PARA INHALACION EN ENVASE A PRESION · BUDESONIDA PULMICTAN INFANTIL 50 microgramos/INHALACION SUSPENSION PARA INHALACION EN ENVASE A PRESION · Miflonide · Miflonide Breezhaler 200 Microgramos Polvo Para Inhalacion (Capsula Dura) · NOVOPULM NOVOLIZER 200 microgramos POLVO PARA INHALACION · NOVOPULM NOVOLIZER 400 microgramos POLVO PARA INHALACION · OLFEX BUCAL 200 microgramos/INHALACION, SUSPENSION PARA INHALACION EN ENVASE A PRESION · OLFEX BUCAL INFANTIL 50 microgramos/INHALACION, SUSPENSION PARA INHALACION EN ENVASE A PRESION · PULMICORT 0,25 mg/ml SUSPENSION PARA INHALACION POR NEBULIZADOR · PULMICORT TURBUHALER 100 microgramos/inhalacion POLVO PARA INHALACION · PULMICORT TURBUHALER 200 microgramos/inhalaci?n POLVO PARA INHALACION · Ribujet 200 Microgramos/Pulsacion Solucion Para Inhalacion en Envase a Presion 
Aircort · Bodinet · Bodix · Budesonide · Budexan · Budineb · Eltairneb · Miflonide · Pulmaxan 
CORTAIR 0,5 mg/ml Suspensie pentru nebulizator · Frenolyn · FRENOLYN 200 ?g · FRENOLYN 400 ?g · Pulmicort 
Budelin Novolizer · Budesonide · Budesonide 200 · Budesonide 400 · Easyhaler Budesonide · Pulmicort 
Budenova · Budesonid Paranova · Budesonid Teva Pharma · Budesonide Stada · Budesonide Teva Pharma · Giona Easyhaler · Miflonide Breezhaler · Pulmicort · Spirocort · Spirocort Turbuhaler 
Budesonid Teva · Giona Easyhaler · Pulmicort 
bds n · Benodil · Budesonide Easyhaler · Budezonid LEK-AM · Budiair · Budipulmi · Budixon Neb · Miflonide Breezhaler · Nebbud · Nebulin · Ondemet · Pulmicort · Resbud · Ribuspir 
Budesonide EG · Novolizer Budesonide · Pulmicort 
Budesonide STADA · Pulmicort 
Budesonid Easyhaler · Budesonide Stada · Budesonide Teva · Novopulmon Novolizer · Pulmicort 
Budesonide Teva · Giona Easyhaler · Pulmicort 
Pulmicort
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