Acute Porphyria Drugs

R03BA05 - Fluticasone

Not porphyrinogenic
NP

Rationale
Probably no significant systemic load. Several references stating non-porphyrinogenicity of glucocorticoids.
Chemical description
Corticosteroid in inhalation aerosol (50 ug/dose) used in treatment of asthma. Plasma levels under detection limit. Used in porphyria ward (Sweden). glucocorticoids EPI-list: safe South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
Similar drugs
Explore alternative drugs in similar therapeutic classes R03B / R03BA or go back.
References
# Citation details PubMed ID
1. Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
9554242
2. Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
9074793
Other sources
3. Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
Tradenames

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