R03CC02 - Salbutamol |
Not porphyrinogenic |
NP |
Rationale
Rather low dose, in large parts excreted unmetabolized. No data pointing to CYP-interaction. Three references consider it safe. Occasional clinical observations of tolerance.
Chemical description
Adrenergic bronchodilator for systemic treatment (tabl. 2 - 4 mg, oral solution 0.4 mg/mL) of asthma, bronchitis and emphysema. Metabolized in the liver. About 35 % excreted in urine in unchanged form. Weak inhibitor of CYP3A4. EPI-list: safe. South African list: use. French list: authorized. Kauppinen and Mustajoki. Prognosis of acute porphyria... Medicine 1992; 71: 1-13: Reported to be tolerated (n=2).
Personal communication
Used in porphyria ward (Sweden).
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases.
Kauppinen R, Mustajoki P. Medicine (Baltimore). 1992 Jan; 71(1):1-13.
|
1549056 |
Tradenames
Ventolin 
Ventolin 
Ventoline 
Aldobronquial · Ventolin 
Broncovaleas · Ventolin 
Salbutamol · Ventolin 
Ventolin 
Salapin · Salbutamol · Ventmax SR · Ventolin · Volmax 
Ventoline 
Salbutamol · Ventolin · Ventoline 
Ventilan · Ventolin · Ventoline 
Salbutamol 
Asmepoc · Salbutamol 
Broncolin · Miflutamol · Salapin · Salbutamol · Salbuvent · Ventolin · Ventolin Spandets · Volmax 
Asmol · Asmol 2 · Asthma · Salbutamol · Venderol · Ventamol · Ventolin · Zenmolin 
Ventolin 
Ventolin 
Ventoline 
Salbutamol · Ventilan · Ventolin 
Ventolin 
Ventolin 
Spalmotil 
Salmo · Ventolin 
Salbutamol · Ventolin 
Albuterol