Acute Porphyria Drugs

Acute Porphyria Drug Database

Monograph

R05CB02 - Bromhexine
Propably not porphyrinogenic
PNP
Rationale
Bromhexine is almost completely metabolized and is a Cyp3A4 substrate. It is not listed as an inducer or MBI of CYPs and in therapeutic use no drug-drug interactions involving CYP enzymes has been observed.
Therapeutic characteristics
Bromhexine is indicated for respiratory disorders with viscous mucus.
Metabolism and pharmacokinetics
Bromhexine is almost completely metabolized. The half-life elimination is 1 hour. Ambroxol is a metabolite of bromhexine and in vitro studies have shown that it is metabolized by CYP3A4 (Ischiguro 2000). In vitro studies have also shown that ambroxol is a weak inhibitor (Ischiguro 2000), which indicates that the potential for drug-drug interactions is low (Ischiguro 2000 and Malerba 2008). The Summary of Product Characteristics also states that interactions with CYP2C9 and CYP3A4 are unlikely and in pharmacotherapeutic use no clinically significant DDIs has been observed (DRUID, Interaktionsdatabasen). This indicates that bromhexine or its metabolites do not act as inducers or inhibitors of CYP enzymes in vivo.
IPNet drug reports
Uneventful use reported in 9 patients with acute porphyria.

References

# Citation details PMID
*Scientific articles
1. Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes.
Ishiguro N, Senda C, et al. Xenobiotica. 2000 Jan;30(1):71-80.
2. Ambroxol in the 21st century: pharmacological and clinical update.
Malerba M, Ragnoli B. Expert Opin Drug Metab Toxicol. 2008 Aug;4(8):1119-29.
 18680446
*Drug interaction databases
3. DRUID bromhexin
4. Interaktionsdatabasen bromhexin
*Summary of Product Characteristics
5. Norwegian medicines agency. Summary of Product Characteristics (SPC). Bromhexin.
Similar drugs
Explore alternative drugs in similar therapeutic classes R05C / R05CB or go back.
Tradenames and packages
From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.
Netherlands
Bisolvon · Bisolvon drank voor kinderen met aardbeiensmaak, 4 mg/5 ml · Bisolvon drank, 8 mg/5 ml · Bisolvon tabletten, 8 mg · Broomhexine · Albert Heijn Broomhexine HCl hoesttabletten 8 mg, tabletten · Albert Heijn Hoestdrank Broomhexine HCl 4 mg/5 ml, drank · Albert Heijn Hoestdrank Broomhexine HCl 8 mg/5 ml, drank · Broomhexine HCI 8 mg Sameko, tabletten · Broomhexine HCl 8 mg, tabletten · Broomhexine HCl CF 4 mg/ 5 ml, drank · Broomhexine HCl CF 8 mg/5 ml, drank · Broomhexine HCl hoestdrank extra sterk suikervrij Sanias 8 mg/5 ml, drank · Broomhexine HCl hoestdrank suikervrij Sanias 4 mg/5 ml, drank · Broomhexine HCl hoesttabletten Sanias 8 mg, tabletten · Broomhexine HCl Linn 8 mg hoesttabletten · Broomhexine HCl Linn 8 mg/5 ml hoestdrank suikervrij, drank · Broomhexine HCl SAM 4 mg/5 ml, drank · Broomhexine HCl SAM 8 mg/5 ml, drank · Broomhexine HCl Teva 4 mg/5 ml, drank · Broomhexine HCl Teva 8 mg/5 ml, drank · DA Hoestdrank Broomhexine HCl 4 mg/5 ml, drank · DA Hoestdrank Broomhexine HCl 8 mg/5 ml, drank · Etos Hoestdrank Broomhexine HCl 4 mg/5 ml, drank · Etos Hoestdrank Broomhexine HCl 8 mg/5 ml, drank · Etos Hoesttabletten Broomhexine HCI 8 mg, tabletten · Hoestdrank HTP Broomhexine HCl 4 mg/5 ml, drank · Hoestdrank HTP Broomhexine HCl 8 mg/5 ml, drank · JUMBO Broomhexine HCl 4 mg/5 ml Hoestdrank, suikervrij, drank · JUMBO Broomhexine HCl 8 mg/5 ml Hoestdrank extra sterk, suikervrij, drank · JUMBO hoesttabletten broomhexine HCl 8 mg, tabletten · Kruidvat broomhexine HCl hoestdrank 4 mg/5 ml suikervrij, drank · Kruidvat broomhexine HCl hoestdrank 8 mg/5 ml extra sterk suikervrij, drank · Kruidvat hoesttabletten broomhexine HCl 8 mg, tabletten · Leidapharm Hoestdrank Broomhexine HCl 4 mg/5 ml, suikervrij, drank · Leidapharm Hoestdrank Broomhexine HCl 8 mg/5 ml, suikervrij, drank · Leidapharm Hoesttabletten Broomhexine HCl 8 mg, tabletten · Livsane Hoestdrank Broomhexine HCl 8 mg/5 ml, drank · Natterman Hoestdrank Broomhexine HCl 4mg/5ml suikervrij, drank · RXT broomhexine HCl 8 mg hoesttabletten, tabletten · Trekpleister broomhexine HCl hoestdrank 4 mg/5 ml suikervrij, drank · Trekpleister broomhexine HCl hoestdrank 8 mg/5 ml extra sterk suikervrij, drank · Trekpleister hoesttabletten broomhexine HCl 8 mg, tabletten · Xelf Broomhexine HCl 4 mg/5 ml, drank · Xelf Broomhexine HCl 8 mg/5 ml, drank · Extra Broomhexine · Natterman Hoestdrank Extra Sterk Broomhexine HCl 8mg/5ml suikervrij, drank
Belgium
Bisolvon · Bisolvon Slijmhoest 0.2 % sol. inhal. nébul. · Bisolvon Slijmhoest 8 mg comp. · Bisolvon Slijmhoest 8 mg/5 ml sirop · Bromhexine · Bromhexine EG 8 mg comp. · Toularynx Bromhexine 5 mg/5 ml sirop
United Kingdom
Bisolvon Chesty · Bisolvon Chesty Forte tablets
Denmark
Bisolvon · Bromhexin · Bromhexin "DAK"
Norway
Bisolvon · Bromheksin Norfri
Poland
Flegafortan · Flegamina Baby · Flegamina Classic · Flegamina Classic Junior o smaku truskawkowym · Flegamina Classic o smaku malinowym · Flegamina Classic o smaku mietowym · Flegamina Classic o smaku mietowym bez cukru · Flegamina Fast · Flegamina Fast Junior · Flegtac Kaszel · Flegtac ORO
Luxembourg
BISOLVON · BISOLVON Toux grasse · Bromhexine · Toularynx Bromhexine
Iceland
Sínex
Finland
Bisolvon · Bisolvon Strong · Medipekt
Latvia
Bromhexin · Bromhexin Sopharma · Bromhexine · Bromhexine-Grindeks
 
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