R06AD01 - Alimemazine |
Probably not porphyrinogenic |
PNP |
Rationale
Phenotiazines in general are considered safe in several references.
Chemical description
High dose (tabl 40-300 mg/d) phenotiazine neuroleptic with sedative and antiallergic properties, used e.g. as tranquillizer in alcoholism, as premedication, in itching and allergic conditions. French list: authorized South African list: use with care Kalman, Bonkowski: safe Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
Tradenames
Theralene 
Variargil 
Alfresed · Alimemazine · Itzenal · Vallergan · Vallergan Forte 
Alfresed · Alimemazin · Nedeltran · Panectyl · Theralen · Theralene · Vallergan 
Alimemazin · Theralene 
Vallergan · Vallergan Forte 
Panectyl 
Alimemazin 
Alimemazina 
Alimemazine