Phenotiazines in general are considered safe in several references.

High dose (tabl 40-300 mg/d) phenotiazine neuroleptic with sedative and antiallergic properties, used e.g. as tranquillizer in alcoholism, as premedication, in itching and allergic conditions. French list: authorized South African list: use with care Kalman, Bonkowski: safe Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

Uneventful use reported in 6 patients with acute porphyria.