Monograph
R06AD03 - Thiethylperazine |
Propably not porphyrinogenic |
PNP |
Rationale
Phenotiazines in general are considered safe in several references.
Chemical description
Antiemetic phenotiazine with sedative effect, also used (supp 20 mg/d) in vertigo. Only 3% of the dose is excreted in unmetabolized form. Kalman, Bonkowski: safe (phenotiazines) Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe (phenotiazines) Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe (phenotiazines)
Similar drugs
Tradenames and packages
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