Monograph

S01EC04 - Brinzolamide

Propably not porphyrinogenic

Rationale

sulfonamide derivative preferentially distributed to red blood cells. Probably insignificant hepatic load. Very long final elimination time from erythrocytes.

Chemical description

sulfonamide used in eyedrops (10 mg/mL) to reduce the intraocular pressure in glaucoma. Isopropyl ester prodrug to an active prostaglandine analogue. Conversion to the active acid form takes place through hydrolysis. Reaches circulation in topical application but due to effective bindnding to erytrocyte carboanhydrases the plasma levels are very low, often lower than 10 ng/ml. Long elimination time in blood; half time about six months. Metabolized by CYPs 3A4 (major enzyme), 2A6, 2C8, 2C9. Brinzolamide and its N-desethyl metabolite is excreted in urine, 20 % as metabolites.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes S01E / S01EC or go back.

Tradenames and packages

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Netherlands

AZOPT · AZOPT 10 mg/ml oogdruppels, suspensie · Brinzo-Vision · Brinzo-Vision 10 mg/ml oogdruppels, suspensie · Brinzolamide · Brinzolamide CF 10 mg/ml, oogdruppels, suspensie · Brinzolamide Mylan 10 mg/ml, oogdruppels, suspensie · Brinzolamide Pharmathen 10 mg/ml oogdruppels, suspensie · Brinzolamide Sandoz 10 mg/ml, oogdruppels, suspensie · Brinzolamide Teva 10 mg/ml, oogdruppels, suspensie · Brizadopt · Brizadopt 10 mg/ml, oogdruppels, suspensie · Optilamid · Optilamid 10 mg/ml, oogdruppels, suspensie

Belgium