Monograph

V03AB15 - Naloxone

Propably not porphyrinogenic

Rationale

Naloxone is most probably not an inhibitor or an inducer of any major CYP enzymes. Several references consider it as safe. Risk for gastrointestinal adverse events in the form of nausea and vomiting motivates vigilance against insufficient intake of food, especially of carbohydrate.

Chemical description

Naloxone is an opioid antagonist.

Therapeutic characteristics

Naloxone may be used for the complete or partial reversal of opioid depression, including mild to severe respiratory depression induced by natural and synthetic opioids. Very common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack is nausea. A common side effect is vomiting.

Metabolism and pharmacokinetics

Naloxone hydrochloride is rapidly metabolised in the liver, mainly by conjugation with glucuronic acid, and excreted in urine. The half-life elimination is 1-1.5 hours. No drug-drug interactions with naloxone as a perpetrator regarding CYP enzymes are observed (Interaksjoner and Interaktionsdatabasen), which indicate that naloxone is not an inhibitor or inducer of CYP enzymes.

Published experience

Naloxone is listed as safe/likely safe (Hunter 1999).

References

#	Citation details	PMID
*	Scientific articles
1.	Anesthetic considerations in hepatic porphyrias. Hunter GH. CRNA. 1999 Feb;10(1):6-14.	10504904
*	Drug interaction databases
2.	Interaksjoner. Naloxone
3.	Interaktionsdatabasen. Naloxone
*	Summary of Product Characteristics
4.	Norwegian medicines agency. Summary of Product Characteristics (SPC). Naloxone.

Citation details

PMID

Scientific articles

Anesthetic considerations in hepatic porphyrias.

Hunter GH. CRNA. 1999 Feb;10(1):6-14.

10504904

Drug interaction databases

Interaksjoner. Naloxone

Interaktionsdatabasen. Naloxone

Summary of Product Characteristics

Norwegian medicines agency. Summary of Product Characteristics (SPC). Naloxone.

Similar drugs

Explore alternative drugs in similar therapeutic classes V03A / V03AB or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Naloxon · Naloxon HCl Accord 0,4 mg/ml, oplossing voor injectie / infusie in een voorgevulde spuit · Naloxon HCl B. Braun 0,4 mg/ml, oplossing voor injectie/infusie · Naloxon HCL-hameln 0,4 mg/ml, oplossing voor injectie/infusie · Naloxon Orpha 0,4 mg/ml, oplossing voor injectie of infusie · Nyxoid · Nyxoid 1,8 mg, neusspray, oplossing · Ventizolve · Ventizolve 1,26 mg neusspray, oplossing in een verpakking voor éénmalig gebruik

Belgium

Naloxon · Naloxon B. Braun 0.4 mg/ml sol. inj./perf. i.v./i.m. amp. · Naloxone · Naloxone Accord 0.4 mg/ml sol. inj./perf. i.v./i.m. ser. préremplie · Nyxoid · Nyxoid 1.8 mg/dose sol. pulv. nas. flac. pulv. · Ventizolve · Ventizolve 1.26 mg sol. pulv. nas. récip. unidose

United Kingdom

Naloxone · Naloxone 1.26mg/0.1ml nasal spray unit dose · Naloxone 2mg/2ml solution for injection pre-filled syringes · Naloxone 2mg/5ml solution for injection Minijet pre-filled syringes · Naloxone 400micrograms/1ml solution for injection ampoules · Naloxone 400micrograms/1ml solution for injection Minijet pre-filled syringes · Naloxone 40micrograms/2ml solution for injection ampoules · Naloxone 800micrograms/2ml solution for injection Minijet pre-filled syringes · Narcan · Narcan 400micrograms/1ml solution for injection ampoules · Narcan Neonatal · Narcan Neonatal 40micrograms/2ml solution for injection ampoules · Nyxoid · Nyxoid 1.8mg/0.1ml nasal spray 0.1ml unit dose · Prenoxad · Prenoxad 2mg/2ml solution for injection pre-filled syringes

Denmark