Monograph
A10BB12 - Glimepiride |
Propably not porphyrinogenic |
PNP |
Rationale
Glimepiride is metabolized by CYP2C9. There are no clinical studies indicating that glipizide is an inhibitor or inducer of CYP enzymes.
Chemical description
Sulfonylourea.
Therapeutic characteristics
Glimepirid is indicated for the treatment of diabetes type 2.
Very rare side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are nausea, vomiting, diarrhoea and abdominal pain. A rare side effect is hypoglycaemia, which also may be potentially porphyrinogenic.
Metabolism and pharmacokinetics
Glimepirid is metabolized mainly by CYP2C9 (Holstein 2012) and the elimination half-life is 5-8 hours.
There are no clinical studies indicating that glipizide is an inhibitor or inducer of CYP enzymes.
IPNet drug reports
Uneventful use reported in 5 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | CYP2C metabolism of oral antidiabetic drugs--impact on pharmacokinetics, drug interactions and pharmacogenetic aspects.
Holstein A, Beil W, Kovacs P. Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1549-63. |
23153186 |
| * | Summary of Product Characteristics | |
| 2. | Norwegian medicines agency. Summary of Product Characteristics (SPC). (glimepirid).
|
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Amaryl 1 mg, tabletten · Amaryl 2 mg, tabletten · Amaryl 3 mg, tabletten · Amaryl 4 mg, tabletten · Amaryl 6 mg, tabletten · Fertin 1 mg, tabletten · Fertin 2 mg, tabletten · Fertin 3 mg, tabletten · Fertin 4 mg, tabletten · Glimepiride Accord 1 mg tabletten · Glimepiride Accord 2 mg tabletten · Glimepiride Accord 3 mg tabletten · Glimepiride Accord 4 mg tabletten · Glimepiride Accord 6 mg tabletten · Glimepiride Aurobindo 1 mg, tabletten · Glimepiride Aurobindo 2 mg, tabletten · Glimepiride Aurobindo 3 mg, tabletten · Glimepiride Aurobindo 4 mg, tabletten · Glimepiride CF 6 mg, tabletten · Glimepiride Sandoz 1, tabletten 1 mg · Glimepiride Sandoz 2, tabletten 2 mg · Glimepiride Sandoz 3, tabletten 3 mg · Glimepiride Sandoz 4, tabletten 4 mg · Glimepiride Sandoz 6 mg, tabletten · Glimepiride Zentiva 1 mg, tabletten · Glimepiride Zentiva 2 mg, tabletten · Glimepiride Zentiva 3 mg, tabletten · Glimepiride Zentiva 4 mg, tabletten · Glimepiride Zentiva 6 mg, tabletten 
Glimepiride EG 2 mg comp. · Glimepiride EG 3 mg comp. · Glimepiride EG 4 mg comp. · Glimepiride Sandoz 2 mg comp. · Glimepiride Sandoz 3 mg comp. · Glimepiride Sandoz 4 mg comp. 
Amaryl · AMARYL 4 mg COMPRIMIDOS · Glimepirida · GLIMEPIRIDA ALTER 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA ALTER 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA APOTEX 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA APOTEX 4 mg COMPRIMIDOS EFG · Glimepirida Aurobindo 2 mg Comprimidos efg · Glimepirida Aurobindo 4 mg Comprimidos efg · Glimepirida Aurovitas 4 mg Comprimidos efg · GLIMEPIRIDA AUROVITAS SPAIN 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA AUROVITAS SPAIN 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA CINFA 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA CINFA 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA COMBIX 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA KERN PHARMA 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA KERN PHARMA 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA MABO 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA MABO 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA NORMON 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA NORMON 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA PENSA 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA PENSA 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA SANDOZ 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA SANDOZ 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA STADA 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA STADA 4 mg COMPRIMIDOS EFG · GLIMEPIRIDA TEVA 2 mg COMPRIMIDOS EFG · GLIMEPIRIDA TEVA 4 mg COMPRIMIDOS EFG · Glimepirida Viatris 2 mg Comprimidos efg · Glimepirida Viatris 4 mg Comprimidos efg · GLIMEPIRIDA ZENTIVA 2 mg COMPRIMIDOS EFG · RONAME 2 mg COMPRIMIDOS · RONAME 4 mg COMPRIMIDOS 
Amaryl · Glimepiride · Solosa 
AMARYL 1mg · AMARYL 2 mg · AMARYL 3 mg · AMARYL 4 mg · AMARYL 6 mg 
Amaryl · Glimepiride · Niddaryl 
Glimepirid Bluefish · Glimepirid Epione Medicine · Glimepirid Nordic Prime · Glimepirid Paranova · Glimepirid Sandoz · Glimepirid Stada · Glimonor 
Glimepirid Teva 
Amaryl 1 · Amaryl 2 · Amaryl 3 · Amaryl 4 · Diaril · Glibetic 1 mg · Glibetic 2 mg · Glibetic 3 mg · Glibetic 4 mg · GlimeHexal 1 · GlimeHexal 2 · GlimeHexal 3 · GlimeHexal 4 · GlimeHexal 6 · Glimepiride Aurovitas · Glimorion · Glitoprel · Symglic 
Glimepiride EG 
Glimeryl 
Oltar · Priglide 
Amaryl · Fertin 
Amaryl® · Limeral® · Melpamid®
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