This combination product contains two substances: metformin (ATC code: A10B A02) and pioglitazone (ATC code: A10B G03). Metformin is safety classified as Not porphyrinogenic (NP) while pioglitazone is safety classified as Probably not porphyrinogenic (PNP). The classification of the combination is according to the most porphyrinogenic of the two substances. For more details please refer to the monographs of the two substances.