Monograph
A10BD08 - Metformin and Vildagliptin |
Propably not porphyrinogenic |
PNP |
Rationale
Neither metformin nor vildagliptin have the potential to inhibit or induce CYP enzymes. No porphyrinogenic physiological effects. Vomiting and loss of appetite is potentially porphyrogenic side effects through interference with nutrition and motivates attendance.
Chemical description
Metformin is a biguanide anti-diabetic. Vildagliptine is a hydroxyadmantane pyrrolidine carbonitrile anti-diabetic.
Therapeutic characteristics
Metformin and vildagliptin are indicated for the improvement of glycaemic control in adult patients with type 2 diabetes mellitus. Vomiting and loss of appetite are potentially porphyrogenic side effects through interference with nutrition intake.
Metabolism and pharmacokinetics
Neither metformin nor vildagliptin are metabolized via CYP enzymes.
References
| # |
Citation details |
PMID |
|---|
| * | Scientific articles |
| 1. |
Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors.
Golightly LK, Drayna CC, et al. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. |
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| 2. |
Clinical pharmacokinetics and pharmacodynamics of vildagliptin.
He YL. Clin Pharmacokinet. 2012 Mar 1;51(3):147-62. |
22339447 |
| 3. |
Pharmacokinetics of dipeptidylpeptidase-4 inhibitors.
Scheen AJ. Diabetes Obes Metab. 2010 Aug; 12(8):648-58. |
20590741 |
| 4. |
Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications.
Tornio A, Niemi M, et al. Trends Pharmacol Sci. 2012 Jun;33(6):312-22. |
22475684 |
| * | Summary of Product Characteristics |
| 5. |
The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Eucreas.
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| * | Other sources |
| 6. |
See also the monographs of metformin (ATC A10BA02) and of vildagliptin (ATC A10BH02).
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Similar drugs
Tradenames and packages
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Norway
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