Monograph
B01AF02 - Apixaban |
Propably not porphyrinogenic |
PNP |
Side effects
One common adverse reaction of apixaban that can be confused with an acute porphyric attack is nausea. This side effect may potentially be porphyrinogenic if leading to a decrease in carbohydrate intake.
Rationale
Apixiban is not reported to be an inducer or a mechanism-based inhibitor of CYP enzymes, and is not observed to alter the metabolism of other CYP metabolized drugs. No pharmacokinetic porphyrinogenic effects are suspected.
Chemical description
Phenylpiperidines
Therapeutic characteristics
Apixaban is an antithrombotic agent, a direct inhibitor of factor Xa, used in the prevention and treatment of thromboembolic diseases. It is administered orally.
Hepatic exposure
Cmax of apixiban is reported to be 80.5 ng/mL (Frost 2014). This is equivalent to 175 nM and hepatic exposure is therefore significant.
Metabolism and pharmacokinetics
Apixaban mainly undergoes O-demethylation and hydroxylation to its metabolites. It is metabolized mainly via CYP3A4/5 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2 (SPC).
Apixaban is neither an inducer of CYP1A2, 2B6 or 3A4/5, nor an inhibitor of CYP1A2, 2A6, 2B6, 2C8, 2C9, 2D6 or 3A4 in vitro. It has been reported to be a weak inhibitor of CYP2C19 in vitro, but this was at concentrations significantly higher than peak plasma concentrations (SPC).
Apixaban is not observed to alter the metabolism of other CYP metabolized drugs (interaksjonsdatabasen.dk, SPC).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | A randomized direct comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban.
Frost C, Song Y, et al. Clin Pharmacol. 2014 Nov 13;6:179-87. |
|
| 2. | In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.
Wang L, Zhang D, et al. Drug Metab Dispos. 2010 Mar;38(3):448-58 |
19940026 |
| * | Drug interaction databases | |
| 3. | Interaktionsdatabasen.dk. Apixaban. Accessible from www.interaktionsdatabasen.dk
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| * | Summary of Product Characteristics | |
| 4. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). (Eliquis).
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Abatixent 2,5 mg filmomhulde tabletten · Abatixent 5 mg filmomhulde tabletten · Apixaban 1A Pharma 2,5 mg, filmomhulde tabletten · Apixaban 1A Pharma 5 mg, filmomhulde tabletten · Apixaban Abdi 2,5 mg filmomhulde tabletten · Apixaban Abdi 5 mg filmomhulde tabletten · Apixaban Accord 2,5 mg, filmomhulde tablet · Apixaban Accord 5 mg, filmomhulde tablet · Apixaban Amarox 2,5 mg, filmomhulde tabletten · Apixaban Amarox 5 mg, filmomhulde tabletten · Apixaban Aurobindo 2,5 mg, filmomhulde tabletten · Apixaban Aurobindo 5 mg, filmomhulde tabletten · Apixaban axunio 2,5 mg filmomhulde tabletten · Apixaban axunio 5 mg filmomhulde tabletten · Apixaban CF 2,5 mg, filmomhulde tabletten · Apixaban CF 5 mg, filmomhulde tabletten · Apixaban Cipla 2,5 mg filmomhulde tabletten · Apixaban Cipla 5 mg filmomhulde tabletten · Apixaban Denk 2,5 mg filmomhulde tabletten · Apixaban Denk 5 mg filmomhulde tabletten · Apixaban HCS 2,5 mg filmomhulde tabletten · Apixaban HCS 5 mg filmomhulde tabletten · Apixaban Hexal 2,5 mg, filmomhulde tabletten · Apixaban Hexal 5 mg, filmomhulde tabletten · Apixaban Indoco 2,5 mg filmomhulde tabletten · Apixaban Indoco 5 mg filmomhulde tabletten · Apixaban Macleods 2,5 mg filmomhulde tabletten · Apixaban Macleods 5 mg filmomhulde tabletten · Apixaban Reddy 2,5 mg filmomhulde tabletten · Apixaban Reddy 5 mg filmomhulde tabletten · Apixaban Sandoz 2,5 mg, filmomhulde tabletten · Apixaban Sandoz 5 mg, filmomhulde tabletten · Apixaban Teva 2,5 mg, filmomhulde tabletten · Apixaban Teva 5 mg, filmomhulde tabletten · Apixaban Viatris 2,5 mg, filmomhulde tabletten · Apixaban Viatris 5 mg, filmomhulde tabletten · Apixaban Vivanta 2,5 mg filmomhulde tabletten · Apixaban Vivanta 5 mg filmomhulde tabletten · Apixaban Xiromed 2,5 mg filmomhulde tabletten · Apixaban Xiromed 5 mg filmomhulde tabletten · Apixaban Zentiva 2,5 mg filmomhulde tabletten · Apixaban Zentiva 5 mg filmomhulde tabletten · Eliquis 0,15 mg granulaat in capsules die moeten worden geopend · Eliquis 0,5 mg omhuld granulaat in sachet · Eliquis 1,5 mg omhuld granulaat in sachet · Eliquis 2 mg omhuld granulaat in sachet · Eliquis 2,5 mg filmomhulde tabletten · Eliquis 5 mg filmomhulde tabletten · Sebuss 2,5 mg filmomhulde tabletten · Sebuss 5 mg filmomhulde tabletten · Sewab 2,5 mg filmomhulde tabletten · Sewab 5 mg filmomhulde tabletten 
Apixaban AB 2.5 mg compr. pellic. · Apixaban AB 5 mg compr. pellic. · Apixaban Accord 2.5 mg compr. pellic. · Apixaban Accord 5 mg compr. pellic. · Apixaban EG 2.5 mg compr. pellic. · Apixaban EG 5 mg compr. pellic. · Apixaban Krka 2.5 mg compr. pellic. · Apixaban Krka 5 mg compr. pellic. · Apixaban Sandoz 2.5 mg compr. pellic. · Apixaban Sandoz 5 mg compr. pellic. · Apixaban Teva 2.5 mg compr. pellic. · Apixaban Teva 5 mg compr. pellic. · Apixaban Viatris 2.5 mg compr. pellic. · Apixaban Viatris 5 mg compr. pellic. · Eliquis · Eliquis 0.15 mg gran. r?cip. unidose · Eliquis 0.5 mg gran. enr. sachet · Eliquis 1.5 mg gran. enr. sachet · Eliquis 2 mg gran. enr. sachet · Eliquis 2.5 mg compr. pellic. · Eliquis 5 mg compr. pellic. 
Apicassa 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apicassa 5 mg Comprimidos Recubiertos con Pelicula efg · Apixab?n Alter 2,5 mg Comprimidos Recubiertos con pel?Cula efg · Apixab?n Alter 5 mg Comprimidos Recubiertos con pel?Cula efg · Apixaban · Apixabán · Apixaban Accord 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Accord 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Aurovitas 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Aurovitas 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Cinfamed 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Combix 2,5 mg Comprimido Recubierto con Pelicula efg · Apixaban Farmaprojects 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Farmaprojects 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Kern Pharma 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Kern Pharma 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Macleods 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Macleods 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Normogen 2,5 mg Comprimidos Recubiertos con pel?Cula efg · Apixaban Olpha 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Olpha 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Pensa 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Pensa 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Ratiopharm 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Ratiopharm 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Sandoz 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Sandoz 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Stada 2,5 mg Comprimidos Recubiertos con pel?Cula efg · Apixaban Stada 5 mg Comprimidos Recubiertos con pel?Cula efg · Apixaban Swanpond Investments 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban tad 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban tad 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Tarbis 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Tecnigen 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Teva 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Teva 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Tevagen 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Torrent 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Viatris 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Viatris 5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Zentiva 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apixaban Zentiva 5 mg Comprimidos Recubiertos con Pelicula efg · Apobilen 2,5 mg Comprimidos Recubiertos con Pelicula efg · Apobilen 5 mg Comprimidos Recubiertos con Pelicula efg · Banrix · Banrix 2,5 mg Comprimidos Recubiertos con pel?Cula efg · Banrix 5 mg Comprimidos Recubiertos con pel?Cula efg · Elibax · Elibax 5 mg Comprimidos Recubiertos con pel?Cula efg · Eliquis 2,5 mg Comprimidos Recubiertos con Pelicula · Eliquis 5 mg Comprimido Recubierto con Pelicula 
Eliquis 
ABATIXENT 2,5 mg · ABATIXENT 5 mg · ABOXOMA 2,5 mg · ABOXOMA 5 mg · APIXABAN GEDEON RICHTER 2,5 mg · APIXABAN GEDEON RICHTER 5 mg · APIXABAN STADA 2,5 mg · APIXABAN STADA 5 mg · APIXABAN TEVA 2,5 mg · APIXABAN TEVA 5 mg · APIXABAN TEVA B.V. 2,5 mg · APIXABAN TEVA B.V. 5 mg · AVOCLOD 2,5 mg · AVOCLOD 5 mg · BANXIOL 2,5 mg · BANXIOL 5 mg · ELIQUIS 2,5 mg · ELIQUIS 5 mg · XAPA 2,5 mg · XAPA 5 mg 
Apixaban · Eliquis 
Apinovia · Apixaban Accord · Apixaban Axunio · Apixaban Cipla · Apixaban Krka · Apixaban Liconsa · Apixaban Medical Valley · Apixaban Orion · Apixaban Pharmapath · Apixaban Sandoz · Apixaban Stada · Apixaban Teva · Apixaban Teva GmbH · Apixaban Viatris · Apixaban Vivanta · Apixaban Zentiva · Apixerin · Apobilen · Baxiren · Eliquis · Pibaxin 
Eliquis 
Abatixent · Aboxoma · Apinoptim · Apixaban Accord · Apixaban Aurovitas · Apixaban Cipla · Apixaban Gedeon Richter · Apixaban Orion · Apixaban Reddy · Apixaban Teva · Apixabanum Teva · Avoclod · Axipio · Banxiol · Baxiren · Eliquis · Poltixa · Prubdaq · Treftenin 
Apixaban EG · Apixaban ratiopharm · Apixaban Viatris · Apixaban-ratiopharm · Eliquis 2,5mg · Eliquis 5mg 
Apixaban Accord · Apixaban Krka · Apixaban Sandoz · Apixaban STADA · Apixaban Teva · Apixaban Teva GmbH · Apixaban Viatris · Apixaban Zentiva · Eliquis 
Apiclodem · Apixaban Accord · Apixaban Cipla · Apixaban Doc Generici · Apixaban Krka · Apixaban Orion · Apixaban ratiopharm · Apixaban ratiopharm GmbH · Apixaban Sandoz · Apixaban Stada · Apixaban Viatris · Eliquis · Modylan · Sebuss · Sislaf 
Abatixent · Aboxoma · Apixaban Accord · Apixaban Adalvo · Apixaban Olpha · Apixaban Teva · Apixaban TevaPharm · Apixaban Viatris · Apixaban Zentiva · Eliquis · Embavi · Modylan · Voziberin 
Aboxoma · Eliquis® · Tapibax® · Trombomelt®
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