Formoterol: Probably insignificant systemic exposure. Fluticasone: Probably no significant systemic load. Several references stating non-porphyrinogenicity of glucocorticoids.

Formoterol: Adrenergic selective beta-2-stimulator with long durationof effect, administered as inhalation powder (12 µg/dose) in bronchial asthma. About 90% of the dose may be swallowed and absorbed. Plasma cancentrations are below the detection limit. Eliminated after direct glucuronidation and 0-demetylation followed by glucuronidation. Fluticasone: Corticosteroid in inhalation aerosol (50 ug/dose) used in treatment of asthma. Plasma levels under detection limit. Used in porphyria ward (Sweden). glucocorticoids EPI-list: safe South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

Formoterol: Uneventful use reported in 4 patients with acute porphyria.